- Mal-PEG4-PFP ester
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2025-06-07
- CAS:1415800-42-8
- Min. Order: 1g
- Purity: >98.00%
- Supply Ability: 1g
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| | Mal-PEG4-PFP Basic information |
| Product Name: | Mal-PEG4-PFP | | Synonyms: | Mal-PEG4-PFP;Mal-PEG5-PFP ester;4,7,10,13-Tetraoxapentadecanoic acid, 15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 2,3,4,5,6-pentafluorophenyl ester;Mal-PEG4-PFP ester;Perfluorophenyl 2-(2-(2-(2-(2,5-dioxo-2H-pyrrol-1(5H)-yl)ethoxy)ethoxy)ethoxy)acetate;(2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]propanoate;perfluorophenyl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12-tetraoxapentadecan-15-oate;Mal-amido-PEG4-PFP Ester | | CAS: | 1415800-42-8 | | MF: | C21H22F5NO8 | | MW: | 511.39 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1415800-42-8.mol |  |
| | Mal-PEG4-PFP Chemical Properties |
| storage temp. | Storage temp. 2-8°C | | form | Viscous Liquid | | color | Off-white to light brown |
| | Mal-PEG4-PFP Usage And Synthesis |
| Description | Mal-PEG4-PFP is a PEG linker with maleimide and PFP moieties. Maleimides are thiol reactive between pH 6.5 and 7.5, forming thiolester bonds. The PFP is amine reactive and forms stable amide bonds. PFP was also found to be less susceptible toward hydrolysis than other amine reactive groups. The hydrophilic PEG linker increases the water solubility of a compound in aqueous environments. Increasing the number of units in the PEG chain ehnahces their solubility properties. | | Uses | Mal-PEG4-PFP ester is a nonclaevable ADC linker containing a Maleimide group, 4-unit PEG and a PFP ester. | | IC 50 | Non-cleavable Linker |
| | Mal-PEG4-PFP Preparation Products And Raw materials |
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