2-甲基檸檬酸
| 中文名稱 | 2-甲基檸檬酸 |
|---|---|
| 中文同義詞 | 2-甲基檸檬酸;(±)-2-甲基檸檬酸[干冰運輸];2-羥基丁烷-1,2,3-三羧酸;化合物 2-METHYLCITRIC ACID;2-Methylcitric acid 2-甲基檸檬酸;阿拉丁 M342109-5mg 2-甲基檸檬酸;2-Methylcitric acid 2-甲基檸檬酸;阿拉丁 M342109-5mg 2-甲基檸檬酸, 98% |
| 英文名稱 | 2-METHYLCITRIC ACID |
| 英文同義詞 | DL-2-METHYLCITRIC ACID;2-Methylcitric Acid (unlabelled);2-Hydroxy-3-methyl-1,2,3-propanetricarboxylic acid;Methylcitric acid;2-METHYLCITRIC ACID;YNOXCRMFGMSKIJ-UHFFFAOYSA-N;2-Methylcitric Acid (mixture of diastereomers) (unlabelled);1,2,3-Butanetricarboxylic acid, 2-hydroxy- |
| CAS號 | 6061-96-7 |
| 分子式 | C7H10O7 |
| 分子量 | 206.15 |
| EINECS號 | |
| 相關類別 | 對照品 |
| Mol文件 | 6061-96-7.mol |
| 結構式 |  |
2-甲基檸檬酸 性質
| 熔點 | 79 °C |
|---|---|
| 沸點 | 313.1±42.0 °C(Predicted) |
| 密度 | 1.637±0.06 g/cm3(Predicted) |
| 儲存條件 | Refrigerator |
| 溶解度 | 可溶于DMSO（少許）、甲醇（少許） |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 2.93±0.20(Predicted) |
| 顏色 | 白色至類白色 |
| 穩(wěn)定性 | 吸濕性 |
|
Human Endogenous Metabolite
|
2-Methylcitric acid (Methylcitric acid) impairs glutamate metabolism and induces permeability transition in brain mitochondria. 2-Methylcitric acid inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM.
2-Methylcitric acid (1-3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca
2+
-loaded mitochondria supported by different substrates.
2-Methylcitric acid behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis. 2-Methylcitric acid does not significantly impair mitochondrial glutamate transport. 2-Methylcitric acid does not significantly impair glutamate mitochondrial transport in liver mitochondria.