CS-2407
| 中文名稱 | CS-2407 |
|---|---|
| 中文同義詞 | 1-((4-羥基-1-(苯基甲基)-4-哌啶基)甲基)-2(1H)-吡啶酮鹽酸鹽;化合物YL0919;化合物YL0919,10 MM DMSO 溶液;YL 0919 ,S0282;Hypidone hydrochloride試劑;抑制劑YL0919;化合物:YL0919 CAS:1339058-04-6;抑制劑YL0919 |
| 英文名稱 | YL 0919 |
| 英文同義詞 | YL0919 hydrochloride;CS-2407;YL0919 (YL-0919;0919;Hypidone hydrochloride;Inhibitor,5-hydroxytryptamine Receptor,Serotonin Receptor,5-HT Receptor,Hypidone,Hypidone hydrochloride,YL 0919,inhibit,YL-0919;1-((1-Benzyl-4-hydroxypiperidin-4-yl)methyl)pyridin-2(1H)-one hydrochloride;Hypidone hydrochloride, 10 mM in DMSO |
| CAS號 | 1339058-04-6 |
| 分子式 | C18H23ClN2O2 |
| 分子量 | 334.84 |
| EINECS號 | |
| 相關(guān)類別 | 抑制劑 |
| Mol文件 | 1339058-04-6.mol |
| 結(jié)構(gòu)式 | ![]() |
CS-2407 性質(zhì)
| 儲存條件 | Store at -20°C |
|---|---|
| 溶解度 | 二甲基亞砜:≥30mg/mL(89.60mM) |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
|
5-HT 1A Receptor
|
YL0919 inhibits the uptake of [ 3 H]-5-HT into rat cerebral cortical synaptosomes and HEK293 cells stably expressing hSERT with IC 50 values of 1.78 nM and 1.93,respectively.YL0919 (0.01 nM-10 μM) concentration-dependently inhibits forskolin-stimulated cAMP formation,? exerts a concentration-dependent inhibitory effect on cAMP formation with an IC 50 of approximately 23.9 nM. And in antagonism studies, WAY-100635?prevents YL0919-mediated inhibition of forskolin-stimulated cAMP formation. YL0919 shows affinities to rat 5-HT1A?receptors, SERTs, NETs, and DATs, it binds to 5-HT1A?receptor, serotonin transporter (SERT) with high affinity (K i =0.19 and 0.72 nM, respectively), but its affinity to NET and DAT are low, blocking [ 3 H]nisoxetine and [ 3 H]win35428 binding with Ki?values of 650 nM and 2652 nM respectively.
YL0919 (oral administration; 1.25 or 5 mg/kg; 4 weeks) and fluoxetine (10 mg/kg) reverses the inhibition of locomotor activity in CUS rats.YL0919 (oral administration; 1.25, 2.5, and 5 mg/kg; 4 weeks) significantly reduces the immobility time in TST in mcie FST in mice. Besides, YL0919 displays no effect on the locomotor activity in a separate OFT. Furthermore, the antidepressant-like effect of YL0919 in TST and FST is completely bunted by coadministration with WAY-100635.
| Animal Model: | Male ICR mice weighing 18–22 g |
| Dosage: | 1.25, 2.5, and 5 mg/kg |
| Administration: | Oral administration |
| Result: | Had an effect on Antidepressant-like mice in TST and FST. |
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/07/06 | S0282 | CS-2407 YL 0919 | 1339058-04-6 | 5mg | 3251.43元 |
| 2026/07/06 | S0282 | CS-2407 YL 0919 | 1339058-04-6 | 25mg | 9819.81元 |
