327610-87-7
| 中文名稱 | 327610-87-7 |
|---|---|
| 中文同義詞 | NO-潑尼松龍;化合物 T19480;NO-潑尼松龍,10 MM DMSO 溶液 |
| 英文名稱 | NO-prednisolone |
| 英文同義詞 | NO-prednisolone;[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 4-(nitrooxymethyl)benzoate;NCX-1015;Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-[[4-[(nitrooxy)methyl]benzoyl]oxy]-, (11β)-;NO prednisolone,NOprednisolone;NO-prednisolone, 10 mM in DMSO |
| CAS號(hào) | 327610-87-7 |
| 分子式 | C29H33NO9 |
| 分子量 | 539.57 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 327610-87-7.mol |
| 結(jié)構(gòu)式 | ![]() |
327610-87-7 性質(zhì)
| 沸點(diǎn) | 736.2±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.39±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 12.30±0.70(Predicted) |
| 顏色 | 白色至黃色 |
|
IL-10
|
NO-prednisolone (NCX-1015), an NO-releasing derivative of Prednisolone, is demonstrated to be more effective than Prednisolone in reducing inflammation, inhibiting cytokine and chemokine generation, and up-regulating the expression of the steroid-sensitive cell-surface marker CD163 in human peripheral blood mononuclear cells Incubation of PBMCs with NO-prednisolone (NCX-1015) and Prednisolone produces a concentration-dependent activation of CD163. NO-prednisolone is more potent than Prednisolone at inducing CD163 cell surface expression. The increased efficacy of NO-prednisolone, compared with the parent molecule Prednisolone, is also observed when assessing inhibition of LPS induced IL-1β production.
In vivo treatment with NO-prednisolone (NCX-1015) potently stimulates IL-10 production, suggesting that the NO steroid induces a regulatory subset of T cells that negatively modulates intestinal inflammation. The two doses of NO-prednisolone tested, 0.5 and 5 mg/kg/day (equivalent to 0.33 and 3.3 mg/kg/day prednisone, respectively) effectively attenuates the severity of the wasting syndrome, ameliorates the colitis score, and reduces the colonic myeloperoxidase (MPO) activity. NO-prednisolone administration also reduces the colonic mRNA and protein content of tumor necrosis factor-α, IL-12, and IFN-γ. NO-prednisolone also reduces the expression of inducible NO synthase and cyclooxygenase-2 but in contrast does not inhibit colonic expression of IL-10 mRNA or protein. In fact, IL-10 expression is enhanced in mice treated with NO-prednisolone.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-101757 | 327610-87-7 NO-prednisolone | 327610-87-7 | 1mg | 1170元 |
| 2026/06/05 | HY-101757 | 327610-87-7 NO-prednisolone | 327610-87-7 | 5mg | 2880元 |
