| Company Name: |
Hunan Hui Bai Shi Biotechnology Co., Ltd.
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| Tel: |
0731-85526065 13308475853 |
| Email: |
ivy@hnhbsj.com |
| Products Intro: |
Product Name:GM3Cer d18:1/18:0 (Neu5Aca2,3Galb1,4GlcbCeramide)
CAS:124579-05-1
Purity:98% HPLC Package:按需包裝
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| Company Name: |
Shanghai Macklin Biochemical Co.,Ltd.
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| Tel: |
15221275939; 15221275939 |
| Email: |
shenlinxing@macklin.cn |
| Products Intro: |
Product Name:Ganglioside GM3
CAS:124579-05-1
Purity:優(yōu)級試劑， 98% Package:1mg；5mg
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Ganglioside GM3 manufacturers
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| | Ganglioside GM3 Basic information |
| Product Name: | Ganglioside GM3 | | Synonyms: | Neu5Aca2,3Galb1,4Glc Ceramide Synonym:GM3;Octadecanamide, N-[(1S,2R,3E)-1-[[[O-(N-acetyl-α-neuraminosyl)-(2→3)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]oxy]methyl]-2-hydroxy-3-heptadecen-1-yl]-;Neu5Acα2, 3Galβ1, 4Glc Ceramide;Neu5Aca2,3Galb1,4Glc Ceramide;Neu5Acα2,?3Galβ1,?4Glc?Ceramide/Neu5Acα2,3Galβ1,4Glc Ceramide/Ganglioside GM3;(2S,4S,5R,6R)-5-Acetamido-2-(((2S,3R,4S,5S,6R)-2-(((2R,3S,4R,5R,6R)-4,5-dihydroxy-6-(((2S,3R,E)-3-hydroxy-2-stearamidooctadec-4-en-1-yl)oxy)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylic acid | | CAS: | 124579-05-1 | | MF: | C59H108N2O21 | | MW: | 1181.51 | | EINECS: | | | Product Categories: | | | Mol File: | 124579-05-1.mol |  |
| | Ganglioside GM3 Chemical Properties |
| Boiling point | 1260.2±65.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | form | Solid | | pka | 1.92±0.70(Predicted) | | color | White to off-white | | InChIKey | UIKPUUZBQYTDRX-WMWRIFHGNA-N |
| | Ganglioside GM3 Usage And Synthesis |
| Uses | Ganglioside GM3-d7 is deuterium labeled Ganglioside GM3. Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia[1][1][2][3]. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Nihei W, et al. NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains. J Lipid Res. 2018 Nov;59(11):2181-2187. DOI:10.1194/jlr.M089201
[3] Inokuchi JI, et al. Pathophysiological Significance of GM3 Ganglioside Molecular Species With a Particular Attention to the Metabolic Syndrome Focusing on Toll-Like Receptor 4 Binding. Front Mol Biosci. 2022 May 30;9:918346. DOI:10.3389/fmolb.2022.918346 |
| | Ganglioside GM3 Preparation Products And Raw materials |
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