1050480-30-2
| 中文名稱 | 1050480-30-2 |
|---|---|
| 中文同義詞 | 化合物 T16523;1-(9-乙基-9H-咔唑-3-基)-N-甲基甲胺鹽酸鹽;PHIKAN 083,P53穩(wěn)定劑;化合物 PHIKAN 083 HYDROCHLORIDE;PhiKan 083 hydrochloride試劑;PhiKan 083 hydrochloride試劑;9-乙基-N-甲基-9H-咔唑-3-甲胺鹽酸鹽 |
| 英文名稱 | PhiKan 083 hydrochloride |
| 英文同義詞 | PhiKan083 hydrochloride >=98% (HPLC);1-(9-Ethyl-9H-carbazol-3-yl)-N-methylmethanamine hydrochloride;PhiKan 083 HCl |
| CAS號(hào) | 1050480-30-2 |
| 分子式 | C16H19ClN2 |
| 分子量 | 274.79 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 1050480-30-2.mol |
| 結(jié)構(gòu)式 |  |
1050480-30-2 性質(zhì)
| 儲(chǔ)存條件 | Store at -20°C |
|---|---|
| 溶解度 | 在水中溶解度為 50 mM，在 DMSO 中溶解度為 100 mM |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
| 水溶解性 | Water: 2 mg/mL (7.28 mM and warming) |
| InChIKey | IXWVUPURFWFRNE-UHFFFAOYSA-N |
| SMILES | CNCC1=CC2=C(C=C1)N(CC)C3=C2C=CC=C3.[H]Cl |
Kd: 167 μM (p53-Y220C), 150 μM (p53 Y220C , in Ln229 cells)
PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes
Y220C
(a
p53
mutant), with a
K
d
of 167 μM, shows a relative binding affinity (K
d
) of 150 μM for p53
Y220C
in Ln229 cells.
PhiKan 083 slows down its thermal denaturation rate.
PhiKan 083 (125 μM, 48 hours) reduces the cell viability of engineered variants of Ln229 cells.
PhiKan 083 (100 μM) in conbination with NSC 123127 (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells (p53
wt
, p53
Y220C
, p53
G245S
, p53
R282W
).
Cell Viability Assay
| Cell Line: | Ln229, Ln229-p53-wt, Ln229-p53-Y220C, Ln229-p53-G245S, Ln229-p53-R282W cells |
| Concentration: | 125 μM |
| Incubation Time: | 48 hours |
| Result: | Caused ～70 ± 5% reduction in cell viability of variants of Ln229 cells. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲(chǔ)類別 | 11 - 可燃固體 |
| 危險(xiǎn)性類別 | 眼部刺激 類別2 經(jīng)皮刺激 類別2 |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-108637A | 1050480-30-2 PhiKan 083 hydrochloride | 1050480-30-2 | 5 mg | 1100元 |
| 2026/06/05 | HY-108637A | 1050480-30-2 PhiKan 083 hydrochloride | 1050480-30-2 | 10 mM * 1 mL in DMSO | 1210元 |