| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Monoclonal Anti-β-Catenin
Purity:monoclonal 6F9, ascites fluid Package:0.2mL, 0.5mL Remarks:C7082
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| Company Name: |
Merck Millipore
|
| Tel: |
1-400-889-1988 400-889-1988 |
| Email: |
bioscience@merckgroup.com |
| Products Intro: |
Product Name:Anti Beta-Catenin
|
| Company Name: |
Neobioscience Co., Ltd.
|
| Tel: |
4006-800-892 |
| Email: |
info@neobioscience.com |
| Products Intro: |
Product Name:Anti Beta-Catenin
|
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| | ANTI-BETA-CATENIN Basic information |
| | ANTI-BETA-CATENIN Chemical Properties |
| storage temp. | -20°C | | biological source | mouse |
| | ANTI-BETA-CATENIN Usage And Synthesis |
| Uses | Monoclonal Anti-β-Catenin antibody produced in mouse has been used in:
- immunohistochemistry
- immunofluorescence
- immunoblotting
| | Uses | Monoclonal Anti-β-Catenin antibody produced in mouse has been used:
- immunoblotting
- immunohistochemistry
- immunolabeling
- immunofluorescence
- immunocytochemical staining
| | General Description | Monoclonal Anti-β-Catenin (mouse IgG1 isotype) is derived from the 15B8 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. β-catenin belongs to the armadillo family and comprises the N-terminal region with 12 imperfect repeatsand a conserved C-terminal region. The locus 3p22.1 in the human chromosome harbors β-catenin gene. β-catenin shares 70% sequence identity to a protein encoded by Drosophila armadillo, a segment polarity gene. Both armadillo and β-catenin share considerable homology with plakoglobin, which has been proposed to be γ-catenin. | | Biochem/physiol Actions | β-catenin is a prime component of the wingless (Wnt) pathway and plays a key role in gene expression during development. The homology between β-catenin and armadillo raised the possibility that β-catenin has a developmental signaling role in vertebrates. β-catenin mediates the interaction of the E-cadherin-catenin complex with the epidermal growth factor (EGF) receptor. β-catenin and plakoglobin are substrates for tyrosine phosphorylation following EGF stimulation of cells. β-catenin also associates with the tumor suppressor protein adenomatous polyposis coli (APC). Monoclonal antibody reacting specifically with β-catenin is an essential tool in defining the interactions and distributions of β-catenin and its relationships with other catenins and cadherins in various cells and tissues. |
| | ANTI-BETA-CATENIN Preparation Products And Raw materials |
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