羥基氯喹EP雜質D-d5二鹽酸
| 中文名稱 | 羥基氯喹EP雜質D-d5二鹽酸 |
|---|---|
| 中文同義詞 | 氯喹相關物質D;去乙基氯喹;去乙基氯喹-D4;去乙基哌拉西林;羥氯喹硫酸EP雜質D DIHBR;脫乙基氯喹DIHBR(硫酸羥氯喹EP雜質D DIHBR);羥基氯喹EP雜質D;羥氯喹雜質9 2HBR |
| 英文名稱 | DESETHYL CHLOROQUINE |
| 英文同義詞 | DESETHYL CHLOROQUINE;Deethylchloroquine;Monodeethylchloroquine;N4-(7-Chloro-4-quinolinyl)-N1-ethyl-1,4-pentanediamine;NSC 13254;WR 29623;4-[[1-Methyl-4-(ethylamino)butyl]amino]-7-chloroquinoline;N'-(7-Chloroquinolin-4-yl)-N-ethyl-1,4-pentanediamine |
| CAS號 | 1476-52-4 |
| 分子式 | C16H22ClN3 |
| 分子量 | 291.82 |
| EINECS號 | |
| 相關類別 | 化學試劑;對照品-雜質對照品;雜質對照品;Metabolite;Various Metabolites and Impurities;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals |
| Mol文件 | 1476-52-4.mol |
| 結構式 |  |
羥基氯喹EP雜質D-d5二鹽酸 性質
| 熔點 | 94-97C |
|---|---|
| 沸點 | 173-175 °C(Press: 0.05 Torr) |
| 密度 | 1.138±0.06 g/cm3(Predicted) |
| 儲存條件 | -20°C Freezer |
| 溶解度 | 可溶于氯仿（少量）、二氯甲烷（少量）、乙酸乙酯（少量） |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 10.62±0.19(Predicted) |
| 顏色 | 淺黃色至深黃色 |
| 生物來源 | synthetic |
| InChI | 1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20) |
| InChIKey | MCYUUUTUAAGOOT-UHFFFAOYSA-N |
| SMILES | ClC(C=C1)=CC2=C1C(NC(CCCNCC)C)=CC=N2 |
Desethyl chloroquine 是 Chloroquine 的主要去乙基代謝產(chǎn)物。Chloroquine 是一種自噬和 toll-like receptors (TLRs) 的抑制劑。Desethyl chloroquine 具有抗瘧原蟲活性。
P. falciparum
Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame.
安全信息
| WGK Germany | 3 |
|---|---|
| 海關編碼 | 2933497050 |
| 存儲類別 | 11 - 可燃固體 |
| 危險性類別 | 急性毒性 類別4 經(jīng)口 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-135811 | 羥基氯喹EP雜質D-d5二鹽酸 Desethyl chloroquine | 1476-52-4 | 2.5 mg | 6180元 |
| 2024/11/08 | HY-135811 | Desethyl chloroquine | 2500 μg | 6180元 |