DCG IV
| 中文名稱 | DCG IV |
|---|---|
| 中文同義詞 | (1R,2R)-3-[(S)-氨基(羧基)甲基]環(huán)丙烷-1,2-二羧酸;(2S,2R,3R)-2-(2,3-二甲基環(huán)丙基)甘氨酸;化合物 T10978;化合物 DCG-IV |
| 英文名稱 | DCG IV |
| 英文同義詞 | DCG IV;(2S,2'R,3'R)-2-(2',3'-DICARBOXYCYCLOPROPYL)GLYCINE;2-(2,3-dicarboxycyclopropyl)glycine;1,2-Cyclopropanedicarboxylic acid, 3-[(S)-aminocarboxymethyl]-, (1R,2R)-;DCG IV,DCGIV;(1R,2R)-3-[(S)-Aminocarboxymethyl]-1,2-cyclopropanedicarboxylic acid;(1R,2R)-3-[(S)-Aminocarboxymethyl]-1,2-cyclopropanedicarboxylic acid (ACI) |
| CAS號(hào) | 147782-19-2 |
| 分子式 | C7H9NO6 |
| 分子量 | 203.15 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 147782-19-2.mol |
| 結(jié)構(gòu)式 |  |
DCG IV 性質(zhì)
| 沸點(diǎn) | 503.9±40.0 °C(Predicted) |
|---|---|
| 密度 | 1.819±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Desiccate at RT |
| 溶解度 | 可微溶于水 |
| 酸度系數(shù)(pKa) | 2.40±0.10(Predicted) |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米白色 |
| 水溶解性 | Soluble to 100 mM in water |
|
mGluR2R 0.35 μM (EC 50 ) |
mGluR3R 0.09 μM (EC 50 ) |
mGluR1R 389 μM (IC 50 ) |
mGluR5 630 μM (IC 50 ) |
mGluR4R 22.5 μM (IC 50 ) |
mGluR6 39.6 μM (IC 50 ) |
mGluR7 40.1 μM (IC 50 ) |
mGluR8 32 μM (IC 50 ) |
DCG-IV is also an NMDA receptor agonist in the rat cortical slice.
DCG-IV (1-10 mg/kg; i.p.) depresses the phencyclidine (PCP)-induced hyperlocomotion.
| Animal Model: | Male ICR mice weighing about 40 g (PCP-induced locomotor activity) |
| Dosage: | 10, 5, or 1 mg/kg |
| Administration: | I.p. |
| Result: | Reduced spontaneous activities of the animals at 10 or 5 mg/kg. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-101335 | DCG-IV | 147782-19-2 | 1 mg | 6437元 |