2-(7-methoxy-4-methylquinazolin-2-yl)guanidine manufacturers
- MPO-IN-28
-
- $43.00
-
2026-07-14
- CAS:37836-90-1
- Purity: 99.02%
- Supply Ability: 10g
|
| | 2-(7-methoxy-4-methylquinazolin-2-yl)guanidine Basic information |
| Product Name: | 2-(7-methoxy-4-methylquinazolin-2-yl)guanidine | | Synonyms: | 2-(7-methoxy-4-methylquinazolin-2-yl)guanidine;Myeloperoxidase inhibitor 28;MPO inhibitor 28;Guanidine, N-(7-methoxy-4-methyl-2-quinazolinyl)-;1-(7-Methoxy-4-methylquinazolin-2-yl)guanidine;inhibit,Inhibitor,Glutathione Peroxidase,MPOIN28,MPO IN 28;MPO-IN-28, 10 mM in DMSO;MPO-IN-28 ，S0316 | | CAS: | 37836-90-1 | | MF: | C11H13N5O | | MW: | 231.25 | | EINECS: | | | Product Categories: | | | Mol File: | 37836-90-1.mol |  |
| | 2-(7-methoxy-4-methylquinazolin-2-yl)guanidine Chemical Properties |
| Boiling point | 442.7±37.0 °C(Predicted) | | density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | DMSO:34.37(Max Conc. mg/mL);148.6(Max Conc. mM) | | form | A solid | | pka | 7.83±0.30(Predicted) | | color | Off-white to light yellow | | InChI | 1S/C11H13N5O/c1-6-8-4-3-7(17-2)5-9(8)15-11(14-6)16-10(12)13/h3-5H,1-2H3,(H4,12,13,14,15,16) | | InChIKey | ZJBMSSBTCGJZEE-UHFFFAOYSA-N | | SMILES | N(c1nc2c(c(n1)C)ccc(c2)OC)\C(=N\[H])\N |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 2-(7-methoxy-4-methylquinazolin-2-yl)guanidine Usage And Synthesis |
| Uses | MPO-IN-28 is a selective myeloperoxidase (MPO) inhibitor with an IC50 of 44 nM. MPO-IN-28 can effectively inhibit MPO-mediated low-density lipoprotein oxidation with an IC50 of 90 nM[1]. | | Biological Activity | Compound 18 is an agonist of Aedes aegypti mosquitoes NPY-like receptor 7 (NPYLR7) th at inhibit mosquito attraction to humans and other hosts. Compound 18 suppresses biting and blood-feeding on a live host. Also, It (MPO-IN-28) is a potent myeloperoxidase (MPO) inhibitor with an IC50 of 44 nM. | | References | [1] Soubhye J, et al. Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors Using Virtual Screening Procedure. J Med Chem. 2017 Aug 10;60(15):6563-6586. DOI:10.1021/acs.jmedchem.7b00285 |
| | 2-(7-methoxy-4-methylquinazolin-2-yl)guanidine Preparation Products And Raw materials |
|