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| | SKULLCAPFLAVONE I Basic information |
| Product Name: | SKULLCAPFLAVONE I | | Synonyms: | SKULLCAPFLAVONE I;5,2'-Dihydroxy-7,8-dimethoxyflavone;5-Hydroxy-2-(2-hydroxyphenyl)-7,8-dimethoxy-4H-1-benzopyran-4-one;Skullcapflavon I;2',5-Dihydroxy-7,8-dimethoxyflavone;4H-1-Benzopyran-4-one, 5-hydroxy-2-(2-hydroxyphenyl)-7,8-dimethoxy-;5-hydroxy-2-(2-hydroxyphenyl)-7,8-dimethoxychromen-4-one;2',5-Dihydroxy 7,8-dimethoxyflavone | | CAS: | 41060-16-6 | | MF: | C17H14O6 | | MW: | 314.29 | | EINECS: | | | Product Categories: | | | Mol File: | 41060-16-6.mol |  |
| | SKULLCAPFLAVONE I Chemical Properties |
| Melting point | 254-256℃ | | Boiling point | 573.6±50.0 °C(Predicted) | | density | 1.402 | | solubility | Soluble in chloroform and methanol; | | form | powder | | pka | 6.81±0.40(Predicted) | | color | Yellow | | Water Solubility | insoluble in water | | InChI | 1S/C17H14O6/c1-21-14-8-12(20)15-11(19)7-13(23-17(15)16(14)22-2)9-5-3-4-6-10(9)18/h3-8,18,20H,1-2H3 | | InChIKey | CZRGNFVQUYWGKP-UHFFFAOYSA-N | | SMILES | OC1=C(C(C=C(C2=CC=CC=C2O)O3)=O)C3=C(OC)C(OC)=C1 |
| WGK Germany | WGK 3 | | Storage Class | 13 - Non Combustible Solids |
| | SKULLCAPFLAVONE I Usage And Synthesis |
| Uses | Skullcapflavone I can be isolated from A. nallamalayana. Skullcapflavone I inhibits collagenase and elastase enzyme with IC50s of 106.74 μM and 186.70 μM. Skullcapflavone I has anticancer activities by down-regulating miR-23a[1]. | | target | Caspase | NO | PGE | IL Receptor | | References | [1] Yang B, et al. Anti-cancer, Anti-collagenase and Anti-elastase Potentials of Some Natural Derivatives: In vitro and in silico Studies. J Oleo Sci. 2023;72(5):557-570. DOI:10.5650/jos.ess22337
[2] Cui J, et al. Skullcapflavone I has a potent anti-pancreatic cancer activity by targeting miR-23a. Biofactors. 2020 Sep;46(5):821-830. DOI:10.1002/biof.1621 |
| | SKULLCAPFLAVONE I Preparation Products And Raw materials |
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