| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:N-(2-AMinoethyl)-5-chloroisoquinoline-8-sulfonaMide
CAS:120615-25-0
Package:100Mg,10Mg
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CKI-7 manufacturers
- CKI-7 free base
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- $88.00
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2026-04-22
- CAS:120615-25-0
- Purity:
- Supply Ability: 10g
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| Product Name: | CKI-7 | | Synonyms: | 8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro- Dihydrochloride;8-[N-(2-Aminoethyl)sulphamoyl]-5-chloroisoquinoline, CKI-7;N-(2-AMinoethyl)-5-chloro-isoquinolin-8-sulphonaMide;N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide;CKI-7 free base;8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro-;CKI 7 free base,CKI7 free base | | CAS: | 120615-25-0 | | MF: | C11H12ClN3O2S | | MW: | 285.75 | | EINECS: | | | Product Categories: | Inhibitors;Protein Kinase Inhibitors and Activators;All Inhibitors | | Mol File: | 120615-25-0.mol |  |
| | CKI-7 Chemical Properties |
| Melting point | 188-190°C | | Boiling point | 499.7±55.0 °C(Predicted) | | density | 1.432±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | H2O: 9 mg/mL | | form | solid | | pka | 7.80±0.50(Predicted) | | color | white |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | HS Code | 2933499090 |
| | CKI-7 Usage And Synthesis |
| Chemical Properties | Off-White Crystalline Solid | | Uses | CKI-7 is found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases. | | Definition | ChEBI: A member of the class of isoquinolines that is isoquinoline-8-sulfonamide which is substituted by chlorine at position 5 and in which the sulfonamide nitrogen is substituted by a 2-aminoethyl group. It is an inhibitor of casein kinase I. | | in vivo | In vivo dose-dependent anti-tumor activity of CKI-7 is demonstrated in a SCID-Beige mouse systemic tumor model utilzing a recently isolated Philadelphia chromosome positive acute lymphoblastic leukemia cell line. Standard cell cycle synchronization studies established that exposure to CKI-7 results in cell cycle dependent caspase 3 activation and apoptotic cell death[2]. | | IC 50 | CK1: 6 μM (IC50); CK1: 8.5 μM (Ki); Cdc7; SGK; MSK1 |
| | CKI-7 Preparation Products And Raw materials |
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