順式-8，11，14-二十烷三烯酸甲酯
| 中文名稱(chēng) | 順式-8，11，14-二十烷三烯酸甲酯 |
|---|---|
| 中文同義詞 | 順式-8，11，14-二十烷三烯酸甲酯;順式-8,11,14-二十碳三烯酸;8,11,14-二十碳三烯酸;二十碳三烯酸(順-8,11,14);全順-8,11,14-二十碳三烯酸;順式 - 8,11,14-二十碳三烯的酸;順-8,11,14-二十碳三烯酸甲酯 (C20:3N6) 溶液;順-8,11,14-二十碳三烯酸甲酯 (C20:3N6) |
| 英文名稱(chēng) | CIS-8,11,14-EICOSATRIENOIC ACID |
| 英文同義詞 | DIHOMO-GAMMA-LINOLENIC ACID-CONTAINING TRIGLYCERIDE;EICOSA-8Z,11Z,14Z-TRIENOIC ACID;CIS,CIS,CIS-8,11,14-EICOSATRIENOIC ACID;CIS-8,11,14-EICOSATRIENOIC ACID;DELTA 8 CIS 11 CIS 14 CIS EICOSATRIENOIC ACID;HOMO-GAMMA-LINOLENIC ACID;homo-γ-linolenic acid;(6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid |
| CAS號(hào) | 1783-84-2 |
| 分子式 | C20H34O2 |
| 分子量 | 306.48 |
| EINECS號(hào) | 217-233-0 |
| 相關(guān)類(lèi)別 | 脂肪酸甲酯;脂肪酸甲酯溶液;合成;脂肪酸;提取;中藥對(duì)照品;Aliphatics;Fatty Acid Derivatives & Lipids;Glycerols |
| Mol文件 | 1783-84-2.mol |
| 結(jié)構(gòu)式 |  |
順式-8，11，14-二十烷三烯酸甲酯 性質(zhì)
| 沸點(diǎn) | 200°C(lit.) |
|---|---|
| 密度 | 0.917±0.06 g/cm3(Predicted) |
| 折射率 | n |
| 閃點(diǎn) | 144 °F |
| 儲(chǔ)存條件 | -20°C |
| 溶解度 | 氯仿：50 mg/mL，澄清，無(wú)色 |
| 酸度系數(shù)(pKa) | 4.77±0.10(Predicted) |
| 形態(tài) | 液體 |
| 顏色 | 無(wú)色至淡黃色 |
| 生物來(lái)源 | plant oil (Borage) |
| BRN | 1796533 |
| 穩(wěn)定性 | 感光 |
| 化妝品成分功效 | 皮膚調(diào)理 |
| InChI | 1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12- |
| InChIKey | HOBAELRKJCKHQD-QNEBEIHSSA-N |
| SMILES | CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O |
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Human Endogenous Metabolite
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Dihomo-γ-linolenic acid attenuates pro-inflammatory gene expression in human and mouse macrophages.
Dihomo-γ-linolenic acid (50?μM; 24 hours) attenuates IFN-γ induced phosphorylation of STAT1 on serine 727.
Dihomo-γ-linolenic acid attenuates IL-1β and TNF-α induced MCP-1 and ICAM-1 expression in human macrophages.
Dihomo-γ-linolenic acid attenuates chemokine-driven monocytic migration and macrophage foam cell formation.
Dihomo-γ-linolenic acid attenuates the expression of SR-A and CD36 in human macrophages.
Dihomo-γ-linolenic acid modulates mitochondrial respiration.
Dihomo-γ-linolenic acid modulates the properties of endothelial cells and VSMC.
Western Blot Analysis
| Cell Line: | THP-1 macrophages |
| Concentration: | 50?μM (pre-treated) |
| Incubation Time: | 24 hours |
| Result: | Attenuated IFN-γ induced phosphorylation of STAT1 on serine 727. |
Dihomo-γ-linolenic acid (8?mg/mouse; i.g; twice a week; for 35 days) inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA.
| Animal Model: | Female nude mice (48 four-week old) |
| Dosage: | 8?mg/mouse |
| Administration: | Oral gavage, twice a week, for 35 days |
| Result: | Suppressed metastasis potential in D5D-KD tumors. |
安全信息
| 提供商 | 語(yǔ)言 |
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英文
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