4-BROMOMETHYL-BENZENESULFONAMIDE manufacturers
|
| | 4-BROMOMETHYL-BENZENESULFONAMIDE Basic information |
| Product Name: | 4-BROMOMETHYL-BENZENESULFONAMIDE | | Synonyms: | 4-(broMoMethyl)benzene-1-sulfonaMide;p-Bromomethylbenzenesulfonamide;4-BROMOMETHYL-BENZENESULFONAMIDE;4-sulfonamide benzyl bromide;Benzenesulfonamide, 4-(bromomethyl)-;4-(bromethyl)benzenesulfonylamide | | CAS: | 40724-47-8 | | MF: | C7H8BrNO2S | | MW: | 250.11 | | EINECS: | | | Product Categories: | | | Mol File: | 40724-47-8.mol |  |
| | 4-BROMOMETHYL-BENZENESULFONAMIDE Chemical Properties |
| Melting point | 191-192℃ | | Boiling point | 386.4±44.0 °C(Predicted) | | density | 1.691 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 9.99±0.10(Predicted) | | Appearance | White to off-white Solid |
| | 4-BROMOMETHYL-BENZENESULFONAMIDE Usage And Synthesis |
| Synthesis | General procedure for the synthesis of p-bromomethylbenzenesulfonamide from 4-bromomethylbenzenesulfonyl chloride:
4.1 Synthesis of acetylsulfonamide (SZ2TA1): ammonia was passed into a solution of compound 1 (1 g, 3.7 mmol) in dichloromethane (DCM, 100 mL) at 0°C for 10 min. Subsequently, brine (20 mL) was added for quenching. The organic phase was separated, dried over anhydrous sodium sulfate, and concentrated. Purification by fast chromatography (eluent ratio: hexane:EtOAc = 2:1) afforded product 17 (900 mg, 96.8% yield).
1H-NMR (250 MHz, acetone-d6) δ: 7.91 (d, J = 10.0 Hz, 2H), 7.67 (d, J = 10.0 Hz, 2H), 6.63 (bs, 2H), 4.74 (s, 2H) ppm. | | References | [1] ChemMedChem, 2011, vol. 6, # 5, p. 816 - 825
[2] Journal of the American Chemical Society, 2008, vol. 130, # 42, p. 13820 - 13821
[3] Patent: WO2012/21486, 2012, A2. Location in patent: Page/Page column 113; 114
[4] Patent: WO2012/21486, 2012, A2. Location in patent: Page/Page column 96; 97
[5] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 5, p. 462 - 467 |
| | 4-BROMOMETHYL-BENZENESULFONAMIDE Preparation Products And Raw materials |
|