Α-突刺蛋白61-75
| 中文名稱(chēng) | Α-突刺蛋白61-75 |
|---|---|
| 中文同義詞 | Α-突刺蛋白61-75 |
| 英文名稱(chēng) | L-Threonine, L-α-glutamyl-L-glutaminyl-L-valyl-L-threonyl-L-asparaginyl-L-valylglycylglycyl-L-alanyl-L-valyl-L-valyl-L-threonylglycyl-L-valyl- |
| 英文同義詞 | L-Threonine, L-α-glutamyl-L-glutaminyl-L-valyl-L-threonyl-L-asparaginyl-L-valylglycylglycyl-L-alanyl-L-valyl-L-valyl-L-threonylglycyl-L-valyl-;α-Synuclein (61-75) |
| CAS號(hào) | 440645-08-9 |
| 分子式 | C60H103N17O23 |
| 分子量 | 1430.58 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | 目錄肽 |
| Mol文件 | 440645-08-9.mol |
| 結(jié)構(gòu)式 |  |
Α-突刺蛋白61-75 性質(zhì)
| 沸點(diǎn) | 1886.8±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.304±0.06 g/cm3(Predicted) |
| 酸度系數(shù)(pKa) | 3.23±0.10(Predicted) |
α-Synuclein (61-75) 是 α-Synuclein 的 61-75 片段。α-Synuclein 是一種豐富的神經(jīng)元蛋白，在突觸前神經(jīng)末梢高度豐富。α-Synuclein 是一種帕金森氏病 (PD) 的生物標(biāo)志物。
Lewy bodies containing α-Synuclein are a neuropathological hallmark of PD, and missense mutations in α-Synuclein (A30P, E46K, H50Q, G51D, A53E, A53T), as well as α-Synuclein gene duplications and triplications, appear to cause PD. Moreover, polymorphisms in regulatory elements of the α-Synuclein gene predispose individuals to PD and are linked to an early onset of the disease. The non-Aβ-amyloid component (NAC) region of α-synuclein is relatively hydrophobic and aggregation-prone in human α-Synuclein but not in mouse α-Synuclein nor in the corresponding homologous region of human β-synuclein. Yet, β-synuclein is more homologous to α-synuclein in the N-terminal sequences (74%) than γ-synuclein (67%).