2'-deoxyuridine 5'-monophosphate manufacturers
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| | 2'-deoxyuridine 5'-monophosphate Basic information |
| Product Name: | 2'-deoxyuridine 5'-monophosphate | | Synonyms: | [(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-oxolan-2-yl]methoxyphosphonic acid;2'-deoxyuridylic acid;2''-Deoxyuridine-5''-monophosphoric acid;2'-Deoxy-5'-uridylic acid;2'-Deoxyuridine 5'-phosphate;2'-Deoxyuridine-5'-monophosphate free acid;5'-Uridylic acid, 2'-deoxy-;dUMP·H2 | | CAS: | 964-26-1 | | MF: | C9H13N2O8P | | MW: | 308.18 | | EINECS: | 213-518-9 | | Product Categories: | | | Mol File: | 964-26-1.mol |  |
| | 2'-deoxyuridine 5'-monophosphate Chemical Properties |
| density | 1.742±0.06 g/cm3(Predicted) | | pka | 1.86±0.10(Predicted) |
| | 2'-deoxyuridine 5'-monophosphate Usage And Synthesis |
| Uses | 2'-Deoxyuridine 5'-monophosphate (dUMP) is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis[1]. | | Definition | ChEBI: A pyrimidine 2'-deoxyribonucleoside 5'-monophosphate having uracil as the nucleobase. | | References | [1] Zachary Newby, et al. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20;45(24):7415-28. DOI:10.1021/bi060152s
[2] Skouloubris S, et al. Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones. Open Biol. 2015 Jun;5(6):150015. DOI:10.1098/rsob.150015 |
| | 2'-deoxyuridine 5'-monophosphate Preparation Products And Raw materials |
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