2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- manufacturers
- AZD-9574
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- $117.00
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2026-06-08
- CAS:2756333-39-6
- Purity: 98.46%
- Supply Ability: 10g
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| | 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- Basic information |
| Product Name: | 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- | | Synonyms: | 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl-;PPAR,Peroxisome proliferator-activated receptors,breast cancer,inhibit,AZD-9574,HRR,HRR-deficient cells,homologous recombination repair,HRD+,AZD 9574,Advanced Solid Malignancy,Inhibitor,aberrant DNA repair,AZD9574;6-fluoro-5-[4-[(5-fluoro-2-methyl-3-oxo-4H-quinoxalin-6-yl)methyl]-1-piperazinyl]-N-methyl-2-pyridinecarboxamide;6-Fluoro-5-[4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydro-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methylpyridine-2-carboxamide;6-Fluoro-5-(4-((5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl)piperazin-1-yl)-N-methylpicolinamide;AZD-9574, 10 mM in DMSO;AZD-9574 ，E2147;6-fluoro-5-[4-[(5-fluoro-2-methyl-3-oxo-4H-quinoxalin-6-yl)methyl]piperazin-1-yl]-N-methylpyridine-2-carboxamide | | CAS: | 2756333-39-6 | | MF: | C21H22F2N6O2 | | MW: | 428.44 | | EINECS: | | | Product Categories: | api | | Mol File: | 2756333-39-6.mol | ![2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- Structure](CAS/20210305/GIF/2756333-39-6.gif) |
| | 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- Chemical Properties |
| density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 8.17±0.20(Predicted) | | form | Solid | | color | White to yellow | | InChI | InChI=1S/C21H22F2N6O2/c1-12-20(30)27-18-14(25-12)4-3-13(17(18)22)11-28-7-9-29(10-8-28)16-6-5-15(21(31)24-2)26-19(16)23/h3-6H,7-11H2,1-2H3,(H,24,31)(H,27,30) | | InChIKey | WXRCLFFPZXJCLS-UHFFFAOYSA-N | | SMILES | C1(C(NC)=O)=NC(F)=C(N2CCN(CC3C=CC4=C(C=3F)NC(=O)C(C)=N4)CC2)C=C1 |
| | 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- Usage And Synthesis |
| Uses | AZD-9574 is a potent and brain penetrant PARP1 inhibitor and shows >8000-fold selectivity for PARP1 compared to PARP2/3/5a/6. AZD-9574 acts by selectively inhibiting and trapping PARP1 at the sites of SSBs. AZD-9574 is an anti-cancer agent and can be used for HRD+breast cancer and advanced solid malignancies research[1]. | | in vivo | AZD-9574 (3 mg/kg) shows sustained tumour growth suppression resulting in a significantly extended survival of tumour-bearing mice, in intracranial xenograft model of breast cancer brain metastases[1]. | | IC 50 | PPAR | | References | [1] Hybrid meeting divulges structures of drug candidates
[2] 1.Kunzah Jamal, et al. Abstract 2609: AZD9574 is a novel, brain penetrant PARP-1 selective inhibitor with activity in an orthotopic, intracranial xenograft model with aberrant DNA repair. Cancer Res(2022) 82 (12_Supplement): 2609. |
| | 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- Preparation Products And Raw materials |
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