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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

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Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:Vacquinol-1
CAS:5428-80-8
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
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Products Intro: Product Name:Vacquinol-1
CAS:5428-80-8
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CAS:5428-80-8
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CAS:5428-80-8
Purity:98.67% Package:1mg;195USD|5mg;430USD|10mg;636USD Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:Vacquinol-1
CAS:5428-80-8
Purity:99% Package:5KG;1KG Remarks:Vacquinol-1

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol manufacturers

  • Vacquinol-1
  • Vacquinol-1 pictures
  • $45.00
  • 2026-06-06
  • CAS:5428-80-8
  • Purity: 99.92%
  • Supply Ability: 10g
  • Vacquinol-1
  • Vacquinol-1 pictures
  • $1.00
  • 2020-01-02
  • CAS:5428-80-8
  • Min. Order: 1KG
  • Purity: Min98% HPLC
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Basic information
Product Name:[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
Synonyms:[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol;4-Quinolinemethanol,2-(4-chlorophenyl)-a-2-piperidinyl-;NSC 13316;NSC 13316;NSC13316;NSC-13316;VACQUINOL 1;VACQUINOL1;NSC13316;NSC-13316;CS-2185;4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl-
CAS:5428-80-8
MF:C21H21ClN2O
MW:352.86
EINECS:
Product Categories:building block
Mol File:5428-80-8.mol
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Structure
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Chemical Properties
Melting point 198-199.5 °C
Boiling point 551.4±50.0 °C(Predicted)
density 1.244±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.25 mg/ml
form A crystalline solid
pka13.22±0.20(Predicted)
color white to beige
InChI1S/C21H21ClN2O/c22-15-10-8-14(9-11-15)20-13-17(16-5-1-2-6-18(16)24-20)21(25)19-7-3-4-12-23-19/h1-2,5-6,8-11,13,19,21,23,25H,3-4,7,12H2
InChIKeyVKLJPGAHSLIQKH-UHFFFAOYSA-N
SMILESClc1ccc(cc1)c2nc3c(c(c2)C(O)C4NCCCC4)cccc3
Safety Information
WGK Germany WGK 3
HS Code 2933499090
Storage Class11 - Combustible Solids
MSDS Information
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Usage And Synthesis
DescriptionVacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture. A key effector of vacquinols is MAPK kinase 4 (MKK4). Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. It induces ATP depletion in glioblastoma cells (IC50 = 3.14 μM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics. Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.
UsesVacquinol-1 is in the vacquinol class of quinine derivatives that stimulate death in glioblastoma cells through massive macropinocytotic vacuolization, ATP depletion and eventual cytoplasmic membrane rupture.
References[1] SATISH SRINIVAS KITAMBI. RETRACTED: Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule.[J]. Cell, 2014, 157 2: 313-328. DOI: 10.1016/j.cell.2014.02.021
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Preparation Products And Raw materials
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