| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:J-1063
CAS:2374772-46-8
Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800
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1H-Pyrazole-1-acetamide, 3-(6-methyl-2-pyridinyl)-N-phenyl-4-thieno[3,2-c]pyridin-2-yl- manufacturers
- J-1063
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- $1520.00
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2026-05-11
- CAS:2374772-46-8
- Purity:
- Supply Ability: 10g
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| | 1H-Pyrazole-1-acetamide, 3-(6-methyl-2-pyridinyl)-N-phenyl-4-thieno[3,2-c]pyridin-2-yl- Basic information |
| | 1H-Pyrazole-1-acetamide, 3-(6-methyl-2-pyridinyl)-N-phenyl-4-thieno[3,2-c]pyridin-2-yl- Chemical Properties |
| Boiling point | 670.9±55.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | pka | 13.39±0.70(Predicted) |
| | 1H-Pyrazole-1-acetamide, 3-(6-methyl-2-pyridinyl)-N-phenyl-4-thieno[3,2-c]pyridin-2-yl- Usage And Synthesis |
| Uses | J-1063 is a potent, selective and orally active ALK5 inhibitor with an IC50 of 0.039 μM. J-1063 shows anti-fibrotic effect by the inhibition of inflammatory infiltration, collagen deposition, and hepatocytes necrosis. J-1063 has the potential for the research of liver fibrosis[1]. | | in vivo | J-1063 (12.5, 25, 50 mg/kg; i.g., one time per day for two weeks) shows no toxic side effects on mice at low dose and is suitable for therapeutic administration[1].
J-1063 (12.5 mg/kg; p.o., daily for two consecutive weeks) shows benefit for TAA-induced liver fibrosis in mice[1]. | Animal Model: | Male C57BL/6 mice[1] | | Dosage: | 12.5, 25, 50 mg/kg | | Administration: | i.g., one time per day, two weeks | | Result: | Showed no toxic side effects on mice at low dose and was suitable for therapeutic administration. |
| Animal Model: | Male C57BL/6 mice[1] | | Dosage: | 12.5 mg/kg | | Administration: | p.o., daily for two consecutive weeks | | Result: | Showed benefit for TAA-induced liver fibrosis in mice. |
| | IC 50 | ALK5 | | References | [1] Zheng GH, et al. The in vitro and in vivo study of a pyrazole derivative, J-1063, as a novel anti-liver fibrosis agent: Synthesis, biological evaluation, and mechanistic analysis. Bioorg Chem. 2022; 122:105715. DOI:10.1016/j.bioorg.2022.105715 |
| | 1H-Pyrazole-1-acetamide, 3-(6-methyl-2-pyridinyl)-N-phenyl-4-thieno[3,2-c]pyridin-2-yl- Preparation Products And Raw materials |
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