4-Fluoro-1H-indole-7-carbonitrile manufacturers
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| | 4-Fluoro-1H-indole-7-carbonitrile Basic information |
| Product Name: | 4-Fluoro-1H-indole-7-carbonitrile | | Synonyms: | 1H-Indole-7-carbonitrile,4-fluoro-(9CI);4-fluoro-1H-indole-7-carbonitrile;7-Cyano-4-fluoro-1H-indole;1H-Indole-7-carbonitrile, 4-fluoro-;7-Cyano-4-fluoroindole;SW-9;SWF-9;4-FLUORO-1H-INDOLE-7-CARBONITRILE 97% | | CAS: | 313337-33-6 | | MF: | C9H5FN2 | | MW: | 160.15 | | EINECS: | | | Product Categories: | HALIDE | | Mol File: | 313337-33-6.mol |  |
| | 4-Fluoro-1H-indole-7-carbonitrile Chemical Properties |
| Boiling point | 357.0±22.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 14.01±0.30(Predicted) | | Appearance | White to off-white Solid |
| | 4-Fluoro-1H-indole-7-carbonitrile Usage And Synthesis |
| Uses | 4-Fluoro-1H-indole-7-carbonitrile is used as a pharmaceutical intermediate. | | Synthesis | Step A: A mixture of 4-fluoro-7-bromoindole (600 mg, 2.8 mmol) with cuprous cyanide (CuCN, 1.004 g, 11.2 mmol) in N,N-dimethylformamide (DMF, 4 mL) was heated and refluxed for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into a methanol solution saturated with ammonia (30 mL) and filtered to remove insoluble residues. The filtrate was subsequently added to a mixture of water (20 mL) and saturated aqueous ammonia solution (20 mL) and extracted with ethyl acetate/ether (1:1, v/v) until thin-layer chromatography (TLC) analysis showed no product residue in the aqueous phase. The organic phases were combined, washed sequentially with saturated saline (2 x 200 mL) and water (200 mL), and dried over anhydrous magnesium sulfate (MgSO4). The organic phase was concentrated under reduced pressure to afford 4-fluoro-7-cyanoindole as a yellow-brown solid (310 mg, 69% yield). | | References | [1] Patent: US6469006, 2002, B1 |
| | 4-Fluoro-1H-indole-7-carbonitrile Preparation Products And Raw materials |
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