1-Thia-2,7-diazaspiro[4.4]nonan-4-ol, 7-[(4-chlorophenyl)methyl]-2-phenyl-, 1,1-dioxide, (4R,5S)-rel-

1-Thia-2,7-diazaspiro[4.4]nonan-4-ol, 7-[(4-chlorophenyl)methyl]-2-phenyl-, 1,1-dioxide, (4R,5S)-rel- Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:E197
CAS:2378515-04-7
Package:50mg;2380USD|100mg;3100USD|25mg;1820USD
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:E197
CAS:2378515-04-7
Purity:99.91% Package:1removed

1-Thia-2,7-diazaspiro[4.4]nonan-4-ol, 7-[(4-chlorophenyl)methyl]-2-phenyl-, 1,1-dioxide, (4R,5S)-rel- manufacturers

  • E197
  • E197 pictures
  • $1820.00
  • 2026-05-12
  • CAS:2378515-04-7
  • Purity: 99.91%
  • Supply Ability: 10g
1-Thia-2,7-diazaspiro[4.4]nonan-4-ol, 7-[(4-chlorophenyl)methyl]-2-phenyl-, 1,1-dioxide, (4R,5S)-rel- Basic information
Product Name:1-Thia-2,7-diazaspiro[4.4]nonan-4-ol, 7-[(4-chlorophenyl)methyl]-2-phenyl-, 1,1-dioxide, (4R,5S)-rel-
Synonyms:1-Thia-2,7-diazaspiro[4.4]nonan-4-ol, 7-[(4-chlorophenyl)methyl]-2-phenyl-, 1,1-dioxide, (4R,5S)-rel-;E197
CAS:2378515-04-7
MF:C19H21ClN2O3S
MW:392.9
EINECS:
Product Categories:
Mol File:2378515-04-7.mol
1-Thia-2,7-diazaspiro[4.4]nonan-4-ol, 7-[(4-chlorophenyl)methyl]-2-phenyl-, 1,1-dioxide, (4R,5S)-rel- Structure
1-Thia-2,7-diazaspiro[4.4]nonan-4-ol, 7-[(4-chlorophenyl)methyl]-2-phenyl-, 1,1-dioxide, (4R,5S)-rel- Chemical Properties
Boiling point 565.7±60.0 °C(Predicted)
density 1.46±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka12.69±0.20(Predicted)
Safety Information
MSDS Information
1-Thia-2,7-diazaspiro[4.4]nonan-4-ol, 7-[(4-chlorophenyl)methyl]-2-phenyl-, 1,1-dioxide, (4R,5S)-rel- Usage And Synthesis
UsesE197 is the inhibitor for DOCK5 that destroys the podosome belt structure of osteoclasts, thereby inhibiting the bone resorption (IC50=3.44 μM in human osteoclast). E197 inhibits the Rac in DOCK5 expressing HEK293 cell with an IC50 of 36 μM. E197 prevents the bone loss in mouse ovariectomized models[1].
References[1] Mounier L, et al., Novel 2,7-Diazaspiro[4,4]nonane Derivatives to Inhibit Mouse and Human Osteoclast Activities and Prevent Bone Loss in Ovariectomized Mice without Affecting Bone Formation. J Med Chem. 2020 Nov 25;63(22):13680-13694. DOI:10.1021/acs.jmedchem.0c01201
1-Thia-2,7-diazaspiro[4.4]nonan-4-ol, 7-[(4-chlorophenyl)methyl]-2-phenyl-, 1,1-dioxide, (4R,5S)-rel- Preparation Products And Raw materials
Tag:1-Thia-2,7-diazaspiro[4.4]nonan-4-ol, 7-[(4-chlorophenyl)methyl]-2-phenyl-, 1,1-dioxide, (4R,5S)-rel-(2378515-04-7) Related Product Information