| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Androgen receptor degrader-3
CAS:2753650-84-7
Package:1removed
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Androgen receptor degrader-3 manufacturers
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| | Androgen receptor degrader-3 Basic information |
| Product Name: | Androgen receptor degrader-3 | | Synonyms: | Androgen receptor degrader-3;Benzamide, N-[trans-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-1,2-dihydro-1-oxo-6-phthalazinyl]-1-piperazinyl]methyl]-1-piperidinyl]-;(Rac)-GDC-2992 | | CAS: | 2753650-84-7 | | MF: | C45H51ClN8O5 | | MW: | 819.39 | | EINECS: | | | Product Categories: | | | Mol File: | 2753650-84-7.mol |  |
| | Androgen receptor degrader-3 Chemical Properties |
| density | 1.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 10.83±0.40(predicted) | | form | Solid | | color | White to off-white |
| | Androgen receptor degrader-3 Usage And Synthesis |
| Uses | PROTAC AR Degrader-6 (Compound 1) is a PROTAC androgen receptor degrader (DC50: 10 nM in VCaP cell). PROTAC AR Degrader-6 blocks the process of androgen receptor transduction and also degrades the receptor itself. PROTAC AR Degrader-6 can be used for prostate cancer research. Pink: AR ligand (HY-130845); Blue: E3 ligase ligand (HY-W1003189); Black: linker (HY-169975)[1]. | | References | [1] Lu HF, et al. Phthaloxidinone compounds, their preparation methods and medical uses. China, WO2021249534 A1.2021-12-16. |
| | Androgen receptor degrader-3 Preparation Products And Raw materials |
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