| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
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orderCN@merckgroup.com |
| Products Intro: |
Product Name:Macrophage Colony-Stimulating Factor
CAS:81627-83-0
Purity:>=98% (SDS-PAGE) Package:10μg Remarks:M9170
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| Company Name: |
Creative Peptides
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| Tel: |
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| Email: |
info@creative-peptides.com |
| Products Intro: |
Product Name:CSF1
CAS:81627-83-0
Purity:>98% Package:1g; 10g;100g;1kg Remarks:Tumor Antigen Derived Peptides
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| Product Name: | HUMAN M-CSF | | Synonyms: | colony-stimulatingfactor1;csf-1;MGI-IM;Monoclonal Anti-CSF1 antibody produced in mouse;MGC31930;ANTI-M-CSF (CENTER) antibody produced in rabbit;Macrophage colony-stimulating factor 1;Processed macrophage colony-stimulating factor 1 | | CAS: | 81627-83-0 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![HUMAN M-CSF Structure]() |
| | HUMAN M-CSF Chemical Properties |
| storage temp. | -20°C | | form | lyophilized powder | | color | white to off-white | | biological source | rat |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 22-24/25-26 | | WGK Germany | 3 | | RTECS | GI5500000 | | Storage Class | 11 - Combustible Solids |
| | HUMAN M-CSF Usage And Synthesis |
| Uses | Antineoplastic; anti-infective
growth factor that acts on both progenitor and mature
cells of the macrophage line. | | Uses | Macrophage Colony-Stimulating Factor from mouse has been used:
- in the initiation of osteoclastogenesis in bone marrow monocyte cells
- to stimulate osteoclast differentiation in non-adherent hematopoietic cell
- for the generation of blood-derived stem cells
| | General Description | M-CSF (macrophage colony-stimulating factor) is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. The protein works through its receptor CSF1R (colony stimulating factor 1 receptor). The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant murine M-CSF is a 36.4kDa homodimeric protein containing two 156 amino acid polypeptide subunits. | | Biochem/physiol Actions | M-CSF (macrophage colony-stimulating factor) is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. M-CSF also works as a pleiotropic growth factor and plays a crucial role in reproduction and organogenesis. Absence of it can result in reduced growth, neurological and reproductive problems, developmental defects in the mammary gland, bone and pancreas. M-CSF is also involved in the pathogenesis of cancer. | | Description | Macrophage Colony Stimulating Factor Human Recombinant produced in E.coli is a disulfide linked homodimer, non-glycosylated, polypeptide chain containing 2 x 159 amino acids and having a total molecular mass of 37.1 KD. MCSF is purified by proprietary chromatographic techniques. | | Source | Escherichia Coli | | Background | Granulocyte/Macrophage Colony-Stimulating Factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. MCSF induces cells of the monocyte/macrophage lineage. MCSF plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. |
| | HUMAN M-CSF Preparation Products And Raw materials |
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