硫鏈絲菌素
| 中文名稱 | 硫鏈絲菌素 |
|---|---|
| 中文同義詞 | 硫活素;硫鏈絲霉素;蘚霉素;硫鏈絲菌素;硫鏈絲菌素(>97%,BC);硫鏈絲菌素A;硫酸絲菌肽;硫鏈絲菌肽 |
| 英文名稱 | THIOSTREPTON |
| 英文同義詞 | Thiostrepton (200 mg);BryaMycin, Thiactin, AlaninaMide, X 146, A 8506, 6761-31;Thiostrepton, froM StreptoMyces sp.;x146;THIOSTREPTON;Alaninamide, L-threonyl-(4S)-2-(1Z)-1-amino-1-propenyl-4,5-dihydro-4-thiazolecarbonyl-2-(1S,2S,3R)-1-amino-2,3-dihydroxy-2-methylbutyl-4-thiazolecarbonyl-2-(5R,6S)-6-2-(1S,2R)-1-amino-2-hydroxypropyl-4-thiazolyl-5-N-(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy;THIOSTREPTION;thiostrepton from streptomyces azureus |
| CAS號 | 1393-48-2 |
| 分子式 | C72H85N19O18S5 |
| 分子量 | 1664.89 |
| EINECS號 | 215-734-9 |
| 相關(guān)類別 | 抗生素、生物堿;抗生素;微生物代謝物;生化試劑;小分子抑制劑;抗生素類;小分子抑制劑，天然產(chǎn)物;醫(yī)藥原料;通用生化試劑-抗生素;抗體;Inhibitors;Organics;RNA-Protein Translation InhibitorsMore...Close...;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics T-ZAntibiotics;Chemical Structure Class;Gene Regulation and Expression;Genetic Marker SelectionAntibiotics;Interferes with Protein SynthesisSpectrum of Activity;L - ZAntibiotics;Mechanism of Action;PeptidesCell Signaling and Neuroscience;Peptide Synthesis/Antibiotics;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;BETAPACE;antibiotic |
| Mol文件 | 1393-48-2.mol |
| 結(jié)構(gòu)式 |  |
硫鏈絲菌素 性質(zhì)
| 熔點 | 248-257°C (dec.) |
|---|---|
| 比旋光度 | D23 -98.5° (glacial acetic acid); -61° (dioxane); -20° (pyridine) |
| 密度 | 1.0824 (rough estimate) |
| 折射率 | 1.6700 (estimate) |
| 儲存條件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | 溶于DMSO或氯仿 |
| 形態(tài) | 類白色粉末 |
| 酸度系數(shù)(pKa) | 10.43±0.46(Predicted) |
| 顏色 | 米白色 |
| 水溶解性 | 0.24g/L(28 ºC) |
| Merck | 13,9440 |
| 穩(wěn)定性 | 從購買之日起 2 年內(nèi)保持穩(wěn)定。 DMSO 中的溶液可在 -20℃ 下保存長達 1 周。 |
| InChIKey | NSFFHOGKXHRQEW-MRQRIGNGNA-N |
Thiostrepton 是一種抗生素，可選擇性抑制 FOXM1。FOXM1 與 YAP/TEAD 復合物結(jié)合。YAP/TEAD/FOXM1 復合物在控制細胞周期的基因調(diào)控區(qū)域結(jié)合可能會影響細胞增殖。
Thiostrepton (0.01-1000 μM; 48 hours) suppresses cell viability in A2780 and HEC-1A.
Cell Viability Assay
| Cell Line: | A2780 and HEC-1A cells |
| Concentration: | 0.01, 0.1, 1, 10, 100, 1000 μM |
| Incubation Time: | 48 hours |
| Result: | The IC 50 s are 1.10 μM in A2780 and 2.22 μM in HEC-1A, respectively. |
Thiostrepton (i.p.; 17 mg/kg) reduces the tumorigenicity of Ewing's sarcoma (EWS) cells. Tumor volumes in control mice have increased ~6-fold from the initiation of treatment, while their Thiostrepton-treated counterparts increase only ~1.7-fold, exhibiting a ~3.5-fold reduction, relative to controls.
| Animal Model: | Athymic (BALB/c nu/nu) nude mice bearing A4573 cells |
| Dosage: | 17 mg/kg |
| Administration: | Administered i.p. |
| Result: | Treatment inhibited the growth of EWS-derived tumors in vivo. |
安全信息
| 提供商 | 語言 |
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英文
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