219757-90-1
| 中文名稱 | 219757-90-1 |
|---|---|
| 中文同義詞 | 化合物 T13021;舒蘭色羅 |
| 英文名稱 | SULAMSEROD |
| 英文同義詞 | SULAMSEROD;RS-100302;Methanesulfonamide, N-[2-[4-[3-(8-amino-7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-3-oxopropyl]-1-piperidinyl]ethyl]- |
| CAS號(hào) | 219757-90-1 |
| 分子式 | C19H28ClN3O5S |
| 分子量 | 445.96 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 219757-90-1.mol |
| 結(jié)構(gòu)式 |  |
219757-90-1 性質(zhì)
| 沸點(diǎn) | 647.8±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.319±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 酸度系數(shù)(pKa) | 11.22±0.40(Predicted) |
Sulamserod 是一種 5-HT4 receptor 拮抗劑，具有抗心律失常的功效。
|
5-HT 4 Receptor
|
Sulamserod (30 mg/kg) prolongs mean ERP (11568 versus 14667 ms, P,0.01) and wavelength (8.360.9 versus 9.960.8 cm, P,0.01), reduces dispersion of ERP (1565 versus 861 ms, P,0.01), and minimally slows conduction velocity (7264 versus 6765 cm/s, P,0.01) in pigs. Sulamserod produces no ventricular electrophysiological effects. Sulamserod terminates atrial flutter in 6 of 8 animals and atrial fibrillation in 8 of 9 animals and prevents reinduction of sustained tachycardia in all animals.