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| | 2,6-Dichloro-3-methyl-5-nitropyridine Basic information |
| | 2,6-Dichloro-3-methyl-5-nitropyridine Chemical Properties |
| Melting point | 70-71 °C(Solv: cyclohexane (110-82-7)) | | Boiling point | 323.5±37.0 °C(Predicted) | | density | 1.537 | | storage temp. | Inert atmosphere,Room Temperature | | pka | -5.36±0.10(Predicted) | | Appearance | Off-white to light yellow Solid |
| | 2,6-Dichloro-3-methyl-5-nitropyridine Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2,6-dichloro-3-methyl-5-nitropyridine-1-oxide from 2-chloro-5-methyl-3-nitropyridine-1-oxide: 2-chloro-5-methyl-3-nitropyridine-1-oxide (4.0 g, 21.2 mmol) was suspended in phosphorus triclosan (ca. 20 mL) and the reaction was heated to reflux temperature for 3 hours. After completion of the reaction, the reaction mixture was carefully poured into preheated water and cooled to room temperature. It was extracted with ethyl acetate (3×), the organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 4.5 g of brown solid. The crude product was purified by fast column chromatography (dichloromethane as eluent and 5% ethyl acetate in heptane solution as elution system) to give 3.56 g (81% yield) of off-white solid. The product was analyzed by GC-MS (EI+) with m/z = 189 and purity >95%. | | References | [1] Patent: WO2010/94645, 2010, A1. Location in patent: Page/Page column 26 |
| | 2,6-Dichloro-3-methyl-5-nitropyridine Preparation Products And Raw materials |
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