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ACTB-1003

ACTB-1003 Suppliers list
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: factory@coreychem.com
Products Intro: Product Name:Urea, N-[4-[4-amino-6-(methoxymethyl)-7-(4-morpholinylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-fluorophenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]
CAS:939805-30-8
Purity:Min98% HPLC Package:1KG;1USD
Company Name: Finetech Industry Limited
Tel: +86-27-8746-5837 +8619945049750
Email: info@finetechnology-ind.com
Products Intro: Product Name:1-[4-[4-amino-6-(methoxymethyl)-7-(morpholin-4-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-fluorophenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
CAS:939805-30-8
Purity:98% Package:1g,10g,25g,100g,500g,1kg Remarks:N/A
Company Name: BOC Sciences
Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Products Intro: Product Name:ACTB-1003
CAS:939805-30-8
Purity:>98% Remarks:Please reach out to us for more information about custom solutions.
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471;
Email: sales@sarms4muscle.com
Products Intro: Product Name:ACTB-1003
CAS:939805-30-8
Purity:99% Package:5KG;1KG Remarks:ACTB-1003
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:ACTB-1003
CAS:939805-30-8
Purity:98% Package:5mg Remarks:V3276
ACTB-1003 Basic information
Product Name:ACTB-1003
Synonyms:ACTB-1003;N-[4-[4-Amino-6-(methoxymethyl)-7-(4-morpholinylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-fluorophenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea;Urea, N-[4-[4-amino-6-(methoxymethyl)-7-(4-morpholinylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-fluorophenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl];ACTB1003;ACTB 1003;1-[4-[4-amino-6-(methoxymethyl)-7-(morpholin-4-ylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-fluorophenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea;FGFR,Fibroblast growth factor receptor,Vascular endothelial growth factor receptor,inhibit,EOC317,Inhibitor,VEGFR,EOC-317,EOC 317;EOC317, 10 mM in DMSO;EDP-317
CAS:939805-30-8
MF:C27H26F5N7O3
MW:591.53
EINECS:
Product Categories:
Mol File:939805-30-8.mol
ACTB-1003 Structure
ACTB-1003 Chemical Properties
density 1.51±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml; Ethanol: 1 mg/ml
pka12.47±0.70(Predicted)
form Powder
color White to off-white
Safety Information
MSDS Information
ACTB-1003 Usage And Synthesis
UsesACTB-1003 is an oral kinase inhibitor which is used in the targeting of cancers.
in vivo

EOC317 (ACTB-1003) is shown to inhibit tumor angiogenesis evident by the inhibition of CD31 staining in tumor sections. EOC317 is combinable with 5-FU or paclitaxel without diminishing the activity or increasing the toxicity of these chemotherapy agents in the HCT-116 colon tumor xenograft model[1].

IC 50FGFR1: 6 nM (IC50); VEGFR2: 2 nM (IC50); Tie-2: 4 nM (IC50)
ACTB-1003 Preparation Products And Raw materials
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