666179-96-0
| 中文名稱 | 666179-96-0 |
|---|---|
| 中文同義詞 | 利哌酮甲磺酸鹽;化合物 T0351L;化合物 Risperidone Mesylate |
| 英文名稱 | Risperidone (Mesylate) |
| 英文同義詞 | Risperidone (Mesylate);APEXIDONE;R-64766;R64766;Risperidone Mesylate salt |
| CAS號 | 666179-96-0 |
| 分子式 | C24H31FN4O5S |
| 分子量 | 506.5901432 |
| EINECS號 | |
| 相關類別 | |
| Mol文件 | 666179-96-0.mol |
| 結(jié)構(gòu)式 |  |
666179-96-0 性質(zhì)
| 儲存條件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 粉末 |
|
5-HT 2A Receptor 4.8 nM (Ki) |
Dopamine D 2 receptor 5.9 nM (Ki) |
P-glycoprotein
|
Risperidone is a serotonin 5-HT 2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D 2 receptor antagonist, with K i s of 4.8, 5.9 nM for 5-HT 2A and dopamine D 2 receptor, respectively. Risperidone dose-dependently inhibited the release of IL-12 in mature DCs, while the production of IL-10 is dose-dependently increased by Risperidone. A high dose of risperidone can induce TNF-α release from mature DCs.
In the first experiment, body weight is found to be slightly but significantly lower in the Risperidone-treated rats as a function of age. Similar to the first experiment, age-dependent differences in body weight are also observed between the three treatment groups in the second locomotor experiment. Rats treated with the 3.0 mg/kg dose of Risperidone weigh less than vehicle-treated rats on postnatal days 35, 38, and 41. The third locomotor experiment involves larger, mixed-sex litters in contrast to the smaller, single-sex litters used in the first two experiments. As noted for the first two experiments, rats treated with Risperidone in the third experiment gain less weight in an age-dependent manner.