| Company Name: |
BioBioPha Co., Ltd.
|
| Tel: |
0871-65217109 13211707573; |
| Email: |
y.liu@mail.biobiopha.com |
| Products Intro: |
Product Name:(-)-Pinoresinol 4-O-glucoside
CAS:41607-20-9
Purity:98.0% Package:5mg Remarks:BBP00190
|
| Company Name: |
Wuxi Zhongkun Biochemical Technology Co., Ltd.
|
| Tel: |
0510-85629785 18013409632 |
| Email: |
sales@reading-chemicals.com |
| Products Intro: |
Product Name:(-)-Pinoresinol 4-O-glucoside
CAS:41607-20-9
Purity:95%+ Package:根據(jù)客戶需求包裝
|
| Company Name: |
Shanghai Yongye Biotechnology Co., Ltd.
|
| Tel: |
86-021-61559134 15921386130 |
| Email: |
3423497944@qq.com |
| Products Intro: |
Product Name:(-)-Pinoresinol 4-O-glucoside
CAS:41607-20-9
Purity:HPLC>=98% Package:5mg/10mg/20mg/100mg/1g/5g
|
|
| | (-)-Pinoresinol 4-O-glucoside Basic information |
| Product Name: | (-)-Pinoresinol 4-O-glucoside | | Synonyms: | Pinoresinol beta-D-glucopyranoside;β-D-Glucopyranoside, (1R,3aS,4R,6aS)-2-methoxy-4-[tetrahydro-4-(4-hydroxy-3-methoxyphenyl)-1H,3H-furo[3,4-c]furan-1-yl]phenyl;(-)-pinoresinol glucoside;(-)-Pinoresinol glucoside | | CAS: | 41607-20-9 | | MF: | C26H32O11 | | MW: | 520.53 | | EINECS: | | | Product Categories: | | | Mol File: | 41607-20-9.mol |  |
| | (-)-Pinoresinol 4-O-glucoside Chemical Properties |
| Boiling point | 752.489±60.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.419±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 9.837±0.35(predicted) |
| | (-)-Pinoresinol 4-O-glucoside Usage And Synthesis |
| Uses | (-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC50 value of 48.13 μM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease[1][2]. | | Definition | ChEBI: (-)-Pinoresinol glucoside is a glycoside and a lignan. | | in vivo | (-)-Pinoresinol 4-O-glucoside (50 mg/kg; p.o.; twenty days) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in mice[2]. | Animal Model: | 27-30 g, Male Swiss albino mice[2] | | Dosage: | 50 mg/kg | | Administration: | P.o.; twenty days | | Result: | Exhibited a hepatoprotective activity in vivo as it lowered AST and ALT levels, caused a prominent decline in serum glucose level by 37.83% in streptozotocin-treated mice with promising elevation in insulin level of 25.37%. |
| | References | [1] Park KR, et al. Effects of PIN on Osteoblast Differentiation and Matrix Mineralization through Runt-Related Transcription Factor. Int J Mol Sci. 2020 Dec 16;21(24):9579. DOI:10.3390/ijms21249579
[2] Youssef FS, et al. Pinoresinol-4-O-β-D-glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo. J Pharm Pharmacol. 2020 Dec;72(12):1830-1839. DOI:10.1111/jphp.13358 |
| | (-)-Pinoresinol 4-O-glucoside Preparation Products And Raw materials |
|