- KC7F2
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- $43.00
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2026-06-02
- CAS:927822-86-4
- Purity: 99.11%
- Supply Ability: 10g
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| | N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide Basic information |
| Product Name: | N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide | | Synonyms: | N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide;N,N'-(2,2'-disulfanediylbis(ethane-2,1-diyl))bis(2,5-dichlorobenzenesulfonamide);N,N'-(Disulfanediylbis(ethane-2,1-diyl))bis(2,5-dichlorobenzenesulfonamide);HIF-1α Translation Inhibitor, KC7F2;Benzenesulfonamide, N,N'-(dithiodi-2,1-ethanediyl)bis[2,5-dichloro-;KC7F2, >98%;HIF-1α Translation Inhibitor, KC7F2 - CAS 927822-86-4 - Calbiochem;2,5-dichloro-N-[2-[2-[(2,5-dichlorophenyl)sulfonylamino]ethyldisulfanyl]ethyl]benzenesulfonamide | | CAS: | 927822-86-4 | | MF: | C16H16Cl4N2O4S4 | | MW: | 570.38 | | EINECS: | | | Product Categories: | Aromatics, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds | | Mol File: | 927822-86-4.mol |  |
| | N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide Chemical Properties |
| Boiling point | 708.8±70.0 °C(Predicted) | | density | 1.583±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | DMSO: soluble20mg/mL, clear | | form | powder | | pka | 9.26±0.50(Predicted) | | color | white to beige | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. | | InChI | 1S/C16H16Cl4N2O4S4/c17-11-1-3-13(19)15(9-11)29(23,24)21-5-7-27-28-8-6-22-30(25,26)16-10-12(18)2-4-14(16)20/h1-4,9-10,21-22H,5-8H2 | | InChIKey | REQLACDIZMLXIC-UHFFFAOYSA-N | | SMILES | ClC1=CC=C(Cl)C=C1S(NCCSSCCNS(C2=C(Cl)C=CC(Cl)=C2)(=O)=O)(=O)=O |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide Usage And Synthesis |
| Description | KC7F2 (927822-86-4) is an inhibitor of HIF-1α (IC50 = 20 μM).1 It inhibited HIF-mediated transcription in cells derived from glioma, breast, and prostate cancers. The mechanism of action of KC7F2 is via down-regulation of HIF-1α protein synthesis accompanied by suppression of phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 and p70 S6 kinase, key regulators of HIF-1α protein synthesis. | | Uses | N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonamide is a hypoxia inducible factor (HIF-1) inhibitor which act via down regulation of HIF-1α synthesis. | | Uses | N,N''-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonamide is a hypoxia inducible factor (HIF-1) inhibitor which act via down regulation of HIF-1α synthesis. | | storage | Store at -20°C | | References | [1] NARITA T, YIN S, GELIN C F, et al. Data from Identification of a Novel Small Molecule HIF-1α Translation Inhibitor[C]//49 1. 2023: 0. DOI:10.1158/1078-0432.c.6517576.v1 |
| | N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide Preparation Products And Raw materials |
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