5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-

5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Suppliers list
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Products Intro: Product Name:5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-
CAS:1332708-14-1
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
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Products Intro: Product Name:PF-4840154
CAS:1332708-14-1
Purity:98.48% Package:1mg;111USD|5mg;342USD|10mg;497USD Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:PF-4840154
CAS:1332708-14-1
Purity:98% Package:5mg Remarks:V4431
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Products Intro: Product Name:PF-4840154
CAS:1332708-14-1
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Products Intro: Product Name:PF-4840154；PF 4840154;PF4840154
CAS:1332708-14-1
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Basic information
Product Name:5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-
Synonyms:5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-;CS-2357;4-[(2-Methylpropyl)amino]-N-(phenylmethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)methyl]-1-piperazinyl]-5-pyrimidinecarboxamide;N-benzyl-4-(isobutylamino)-2-(4-((tetrahydro-2H-pyran-3-yl)methyl)piperazin-1-yl)pyrimidine-5-carboxamide;PF 4840154,PF-4840154,licking,nocifensive,Inhibitor,non-electrophilic,PF4840154,inhibit,Transient receptor potential channels,behavior,TRP Channel;N-benzyl-4-[(2-methylpropyl)amino]-2-{4-[(oxan-3-yl)methyl]piperazin-1-yl}pyrimidine-5-carboxamide;PF-4840154, 10 mM in DMSO
CAS:1332708-14-1
MF:C26H38N6O2
MW:466.62
EINECS:
Product Categories:
Mol File:1332708-14-1.mol
5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Structure
5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Chemical Properties
density 1.164±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.1 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
form A crystalline solid
pka13.71±0.46(Predicted)
color White to off-white
Safety Information
MSDS Information
5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Usage And Synthesis
UsesPF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC50s of 97 and 23 nM, respectively. PF-4840154 elicits TrpA1-mediated nocifensive behaviour in mouse[1].
Biological ActivityPF-4840154 is a potent and selective rat and human TrpA1 channel agonist with EC50 of 97 and 23 nM, respectively. PF-4840154 induces TrpA1-mediated nociceptive behavior in mice.
in vivo

PF-4840154 (30 nmol; intraplantar) elicits TrpA1-mediated nocifensive behaviour in mouse.

Animal Model: Female CD1 mice (25-30g) (In TrpA1+/+ mice)
Dosage: 30 nmol
Administration: Intraplantar (i.pl) injection
Result: Elicited robust licking behavior.
target

IC50: 97 nM (rTrpA1), 23 nM (hTrpA1)

References[1] Ryckmans T, et al. Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4857-4859. DOI:10.1016/j.bmcl.2011.06.035
5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Preparation Products And Raw materials
Tag:5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-(1332708-14-1) Related Product Information
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