| Company Name: |
Haoyuan Chemexpress Co., Ltd.
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| Tel: |
021-58950125 |
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info@chemexpress.com |
| Products Intro: |
Product Name:CDDO-EA
CAS:932730-51-3
Purity:>98% Package:1293RMB/2mg
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| | CDDO-EA Basic information |
| Product Name: | CDDO-EA | | Synonyms: | CDDO-EA;Bardoxolone ethyl amide;CDDO ethyl amide;CDDO ETHYL AMIDE;RTA405;TP319;RTA 405;TP 319;RTA-405;TP-319;CDDO-EA
(CDDO ethyl amide;RTA 405;RTA405;RTA-405 | | CAS: | 932730-51-3 | | MF: | C33H46N2O3 | | MW: | 518.73 | | EINECS: | | | Product Categories: | | | Mol File: | 932730-51-3.mol |  |
| | CDDO-EA Chemical Properties |
| Boiling point | 670.7±55.0 °C(Predicted) | | density | 1.13±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: ≥ 34 mg/mL (65.54 mM) | | form | Powder | | pka | 16.21±0.70(Predicted) | | color | White to off-white |
| | CDDO-EA Usage And Synthesis |
| Uses | CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator. | | Biological Activity | CDDO-EA is a NF-E2-related factor 2/antioxidant response element (Nrf2/ARE) activator. | | in vitro | CDDO-EA potently activates Nrf2/ARE in a cell culture model of ALS and in the G93A SOD1 mouse model of ALS. CDDO-EA is a potent inducer of apoptosis in A549 lung cancer cells, as shown both by PARP cleavage and Annexin staining. It is more potent than CDDO itself as inducers of heme oxygenase-1 (HO-1). In RAW264.7 macrophage-like cells, CDDO-EA is 7-fold more potent than CDDO as suppressors of the ability of IFN-γ to induce iNOS. | | in vivo | The survival analysis shows that G93A mice treated with CDDO-EA, compared to G93A littermate controls, lives significantly longer. CDDO-EA treatment increases the life-span by 20.6 days from 124.05±3.7 days to 144.72±8.1 days (16.6%) (p<0.001). In CDDO-EA-treated G93A mice, the age of death is 141.4±5.2 days and the duration from the age of onset to the age of death is 57.6±7.6 days, which means that the age of death from onset is prolonged by 17.5 days (43%). | | target | | | References | [1] Neymotin A, et al. Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radic Biol Med. 2011 Jul 1;51(1):88-96. DOI:10.1016/j.freeradbiomed.2011.03.027
[2] Liby K, et al. The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. Cancer Res. 2007 Mar 15;67(6):2414-9. DOI:10.1158/0008-5472.CAN-06-4534 |
| | CDDO-EA Preparation Products And Raw materials |
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