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| | Bromoacetamido-PEG2 -Boc-amine Basic information |
| Product Name: | Bromoacetamido-PEG2 -Boc-amine | | Synonyms: | Bromoacetamido-PEG2 -Boc-amine;Bromoacetamido-PEG2-NH-Boc;tert-Butyl (2-(2-(2-(2-bromoacetamido)ethoxy)ethoxy)ethyl)carbamate;Bromoacetamido-PEG3-t-Boc-N-Amide;Bromoacetamido-C2-PEG2-NH-Boc;BrCH2CONH-PEG2-NHBoc;5,8-Dioxa-2,11-diazatridecanoic acid, 13-bromo-12-oxo-, 1,1-dimethylethyl ester;N-[2-[2-[2-(Boc-amino)ethoxy]ethoxy]ethyl]-2-bromoacetamide | | CAS: | 182244-33-3 | | MF: | C13H25BrN2O5 | | MW: | 369.25 | | EINECS: | | | Product Categories: | | | Mol File: | 182244-33-3.mol |  |
| | Bromoacetamido-PEG2 -Boc-amine Chemical Properties |
| Boiling point | 506.5±50.0 °C(Predicted) | | density | 1.285±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | form | Solid | | pka | 12.23±0.46(Predicted) | | color | White to off-white |
| | Bromoacetamido-PEG2 -Boc-amine Usage And Synthesis |
| Description | Bromoacetamido-PEG2-Boc-amine is a PEG linker containing a Boc protected amine and a bromide group. The protected amine can be deprotected under mild acidic conditions. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | Bromoacetamido-C2-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Bromoacetamido-PEG2 -Boc-amine Preparation Products And Raw materials |
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