2-(2-氨基乙氧基)-5-氯-N-(2-氯-4-硝基苯基)苯甲酰胺鹽酸鹽
| 中文名稱 | 2-(2-氨基乙氧基)-5-氯-N-(2-氯-4-硝基苯基)苯甲酰胺鹽酸鹽 |
|---|---|
| 中文同義詞 | 2-(2-氨基乙氧基)-5-氯-N-(2-氯-4-硝基苯基)苯甲酰胺鹽酸鹽;STAT3抑制劑(HJC0152 HYDROCHLORIDE);化合物HJC0152 HYDROCHLORIDE;HJC0152,STAT3 的抑制劑;化合物HJC0152 HYDROCHLORIDE,10 MM DMSO 溶液;HJC0152 HYDROCHLORIDE/HJC0152 HCL |CAS 1420290-99-8;HJC0152 試劑;HJC0152 ,S8561 |
| 英文名稱 | HJC0152 |
| 英文同義詞 | HJC0152;2-(2-Aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide HCl;2-(2-aminoethoxy)-5-chloro-N-(2-chloro-4- nitrophenyl)benzamide hydrochloride;Benzamide, 2-(2-aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)-, hydrochloride (1:1);HJC0152 hydrochloride;HJC0152 HCl;Inhibitor,Apoptosis,HJC 0152,HJC0152 hydrochloride,inhibit,STAT,HJC-0152,HJC-0152 hydrochloride;HJC0152 hydrochloride, 10 mM in DMSO |
| CAS號 | 1420290-99-8 |
| 分子式 | C15H14Cl3N3O4 |
| 分子量 | 406.64836 |
| EINECS號 | |
| 相關類別 | 細胞生物學試劑 |
| Mol文件 | 1420290-99-8.mol |
| 結構式 |  |
2-(2-氨基乙氧基)-5-氯-N-(2-氯-4-硝基苯基)苯甲酰胺鹽酸鹽 性質
| 儲存條件 | Store at -20°C |
|---|---|
| 溶解度 | DMF:0.1(最大濃度 mg/mL);0.25(最大濃度 mM) DMSO:30.33(最大濃度 mg/mL);74.59(最大濃度 mM) |
| 形態(tài) | 結晶固體 |
| 顏色 | 淺黃至黃色 |
| InChI | InChI=1S/C15H13Cl2N3O4.ClH/c16-9-1-4-14(24-6-5-18)11(7-9)15(21)19-13-3-2-10(20(22)23)8-12(13)17;/h1-4,7-8H,5-6,18H2,(H,19,21);1H |
| InChIKey | XRZHLOYBZOONSZ-UHFFFAOYSA-N |
| SMILES | Cl.NCCOC1C=CC(Cl)=CC=1C(NC1C=CC([N+]([O-])=O)=CC=1Cl)=O |
|
STAT3
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HJC0152 hydrochloride (compound 11) significantly inhibits cell proliferation and induces apoptosis accompanying cellular morphological changes at concentrations of 1, 5, and 10 μM. Results show that treatment with 10 μM HJC0152 hydrochloride decreases the STAT3 promoter activity in MDA-MB-231 cells by approximately 32%, and increasing the dose of HJC0152 hydrochloride to 20 μM further decreases STAT3 promoter activity by 62% as compare with control. Total STAT3 is reduced after treatment with HJC0152 hydrochloride. HJC0152 hydrochloride induces cleaved caspase-3 and down regulates cyclin D1 in MDA-MB-231 cells.
Mice treated with 7.5 mg/kg of HJC0152 hydrochloride (compound 11) via ip show a better effect in inhibiting tumor growth. The growth of xenograft tumors in mice is significantly reduced by HJC0152 hydrochloride at a dose of 25 mg/kg. It is also noteworthy that HJC0152 hydrochloride does not show significant signs of toxicity at a dose of 75 mg/kg.
安全信息
| 更新日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-100602 | 2-(2-氨基乙氧基)-5-氯-N-(2-氯-4-硝基苯基)苯甲酰胺鹽酸鹽 HJC0152 hydrochloride | 1420290-99-8 | 5mg | 700元 |
| 2026/06/05 | HY-100602 | 2-(2-氨基乙氧基)-5-氯-N-(2-氯-4-硝基苯基)苯甲酰胺鹽酸鹽 HJC0152 | 1420290-99-8 | 10 mM * 1 mLin DMSO | 770元 |