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NSC5844

NSC5844 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: CAS:140926-75-6
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:RE-640
CAS:140926-75-6
Purity:99.91% Package:5mg;29USD|10mg;53USD|25mg;88USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:NSC-5844 (RE-640)
CAS:140926-75-6
Purity:98% Package:10mg Remarks:V5036
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:NSC5844；RE-640
CAS:140926-75-6
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；2 mg；25 mg；5 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel: 13417589054
Email: trendseenbio@gmail.com
Products Intro: Product Name:NSC5844(RE640)
CAS:140926-75-6
Purity:99% Package:1kg；25kg

NSC5844 manufacturers

  • RE-640
  • RE-640 pictures
  • $29.00
  • 2026-05-11
  • CAS:140926-75-6
  • Purity: 99.91%
  • Supply Ability: 10g
NSC5844 Basic information
Product Name:NSC5844
Synonyms:NSC5844;N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine;1,2-Ethanediamine, N1,N2-bis(7-chloro-4-quinolinyl)-;RE-640;RE640;RE 640;NSC 5844; NSC-5844; RE 640; RE-640; RE640;NSC5844 (RE640)
CAS:140926-75-6
MF:C20H16Cl2N4
MW:383.27
EINECS:
Product Categories:
Mol File:140926-75-6.mol
NSC5844 Structure
NSC5844 Chemical Properties
Boiling point 632.6±55.0 °C(Predicted)
density 1.431±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 0.33 mg/ml; DMSO: 0.25 mg/ml; Ethanol: slightly soluble
form A crystalline solid
pka6.61±0.50(Predicted)
color White to off-white
Safety Information
MSDS Information
NSC5844 Usage And Synthesis
DescriptionNSC 5844 is a bis-quinoline with diverse biological activities. It inhibits the growth of P. falciparum strains that are sensitive (D-6) and resistant (W-2) to chloroquine in vitro (IC50s = 17 and 27 nM, respectively) but lacks activity against P. berghei in vivo. NSC 5844 inhibits the growth of MDA-MB-468 and MCF-7 breast cancer cells with GI50 values of 7.35 and 14.80 μM, respectively. It also inhibits 24% of botulinum neurotoxin serotype A light chain (BoNT/A LC) metalloprotease activity at a concentration of 20 μM.
UsesN1,N2-Bis(7-chloroquinolin-4-yl)ethane-1,2-diamine and other bisquinoline derivatives have potentials against chloroquine-resistant malaria. A useful intermediate for the preparation of other antimalarial bisaminoquinlines.
IC 50Plasmodium
References[1] JONATHAN L. VENNERSTROM. Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria[J]. Journal of Medicinal Chemistry, 1992, 35 11: 2129-2134. DOI: 10.1021/jm00089a025
[2] HAIWEN ZHANG . Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives[J]. Biomedicine & Pharmacotherapy, 2008, 62 2: Pages 65-69. DOI: 10.1016/j.biopha.2007.04.007
[3] JAMES C BURNETT . Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity[J]. Biochemical and biophysical research communications, 2003, 310 1: Pages 84-93. DOI: 10.1016/j.bbrc.2003.08.112
NSC5844 Preparation Products And Raw materials
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