866927-10-8
| 中文名稱 | 866927-10-8 |
|---|---|
| 中文同義詞 | 化合物IC87201;2-(((1H-苯并[D][1,2,3]三唑-6-基)氨基)甲基)-4,6-二氯苯酚;IC 87201,NNOS-PSD95蛋白-蛋白相互作用抑制劑;化學(xué)試劑/IC87201;化合物IC87201,10 MM DMSO 溶液 |
| 英文名稱 | IC87201 |
| 英文同義詞 | IC87201;IC87201 >=98% (HPLC);Phenol, 2-[(1H-benzotriazol-6-ylamino)methyl]-4,6-dichloro-;IC-87201 (IC87201;2-[(1H-Benzotriazol-6-ylamino)methyl]-4,6-dichlorophenol;2-(((1H-Benzo[d][1,2,3]triazol-6-yl)amino)methyl)-4,6-dichlorophenol;IC 87201,IC87201,IC-87201,inhibit,iGluR,Inhibitor,Ionotropic glutamate receptors;2-{[(1H-1,2,3-benzotriazol-6-yl)amino]methyl}-4,6-dichlorophenol |
| CAS號 | 866927-10-8 |
| 分子式 | C13H10Cl2N4O |
| 分子量 | 309.15 |
| EINECS號 | |
| 相關(guān)類別 | API |
| Mol文件 | 866927-10-8.mol |
| 結(jié)構(gòu)式 |  |
866927-10-8 性質(zhì)
| 儲存條件 | Store at -20°C |
|---|---|
| 溶解度 | DMF:30.0(最大濃度 mg/mL);97.04(最大濃度 mM) DMSO:29.0(最大濃度 mg/mL);93.81(最大濃度 mM) DMSO:PBS ( pH 7.2) (1:3):0.25(最大濃度 mg/mL);0.81(最大濃度 mM) 乙醇:1.0(最大濃度 mg/mL);3.23(最大濃度 mM) |
| 形態(tài) | 固體 |
| 顏色 | 粉紅至紅色 |
| InChI | InChI=1S/C13H10Cl2N4O/c14-8-3-7(13(20)10(15)4-8)6-16-9-1-2-11-12(5-9)18-19-17-11/h1-5,16,20H,6H2,(H,17,18,19) |
| InChIKey | QEHVTUCLCBXQIC-UHFFFAOYSA-N |
| SMILES | C1(O)=C(Cl)C=C(Cl)C=C1CNC1C=C2NN=NC2=CC=1 |
IC87201 (500-1800 μM) does not inhibit any of the probe-PDZ interactions involving PDZ1, PDZ2, PDZ3 of PSD-95 or nNOS-PDZ, or bind the canonical PDZ ligand binding sites. IC87201 binds to the β-finger of nNOS-PDZ and allosterically inhibits the nNOS-PDZ/PSD-95-PDZ interactions. IC87201 shows high degree of fluorescence-based artefactual signal when using TAMRA-nNOS as probe. IC87201 (20 μM) suppresses NMDA-stimulated cGMP formation relative to vehicle, in cultured hippocampal neurons. IC87201 (10 and 100 nM) attenuats NMDA/glycine-induced decreases in neurite outgrowth. IC87201 dose-dependently reduces NMDA-induced cGMP production in primary hippocampal neurons (DIV 14-21) with an IC 50 of 2.7 μM. IC87201 increases the number of branches at 10-30 μM when compared to control-treated neurons.
IC87201 (1, 4 and 10 mg/kg, i.p.) does not produce impairment in either spatial working memory or source memory. IC87201 (1 mg/kg) is effective in treating NMDA-induced thermal hyperalgesia in mice, with a corresponding peak plasma level of 55 ng/mL (or 0.2 μM).
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 危險性類別 | 眼部刺激 類別2 經(jīng)皮刺激 類別2 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-100457 | IC87201 | 866927-10-8 | 5 mg | 500元 |
| 2026/06/05 | HY-100457 | 866927-10-8 IC87201 | 866927-10-8 | 10mM * 1mLin DMSO | 550元 |