867164-40-7
| 中文名稱 | 867164-40-7 |
|---|---|
| 中文同義詞 | TRC051384游離態(tài);化合物TRC 051384;1-(2-嗎啉乙基)-3-(4-(3-(6-嗎啉吡啶-2-基)丙烯?；?苯基)脲;TRC 051384,熱休克蛋白HSP70的誘導(dǎo)物;化合物TRC 051384,10 MM DMSO 溶液 |
| 英文名稱 | TRC 051384 |
| 英文同義詞 | TRC 051384; TRC-051384;N-[2-(4-Morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea;Urea, N-[2-(4-morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-;1-(2-Morpholinoethyl)-3-(4-(3-(6-morpholinopyridin-2-yl)acryloyl)phenyl)urea;HSP,TRC-051384,TRC051384,Heat shock proteins,Inhibitor,inhibit;TRC051384, 10 mM in DMSO;TRC051384 |
| CAS號 | 867164-40-7 |
| 分子式 | C25H31N5O4 |
| 分子量 | 465.54 |
| EINECS號 | |
| 相關(guān)類別 | API |
| Mol文件 | 867164-40-7.mol |
| 結(jié)構(gòu)式 |  |
867164-40-7 性質(zhì)
| 沸點 | 685.7±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.260±0.06 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | 不溶于乙醇；不溶于水； DMSO 中≥109 mg/mL |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 13.47±0.46(Predicted) |
| 顏色 | 粘黃色 |
| SMILES | O=C(C1=CC=C(NC(NCCN2CCOCC2)=O)C=C1)/C=C/C3=CC=CC(N4CCOCC4)=N3 |
|
HSP70
|
TRC051384, dose dependently induces HSP70B mRNA by several hundred folds in both HeLa and rat primary mixed neurons. Treatment with TRC051384 results in significant dose-dependent increase in HSF1 transcriptional activity and recovery of luciferase activity. TRC051384 results in 60% inhibition at 6.25 μM and 90% inhibition at 12.5 μM of LPS-induced TNF-α expression in differentiated THP-1 cell line.
Treatment with TRC051384 significantly reduces stroke associated neuronal injury (87% reduction in area of penumbra recruited to infarct, and 25% reduction in brain edema) and disability in a rat model of transient ischemic stroke even when administered 8 hours post onset of ischemia. Significant improvement in survival (50% by day2 and 67.3% by day 7) is observed with TRC051384 treatment initiated at 4 hours after ischemia onset. Induction of HSP70 by TRC051384 involves HSF1 activation and results in elevated chaperone and anti-inflammatory activity.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-101712 | TRC051384 | 867164-40-7 | 1 mg | 400元 |
| 2026/06/05 | HY-101712 | 867164-40-7 TRC051384 | 867164-40-7 | 5mg | 900元 |