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| | N'-Cbz-L-ornithine Basic information |
| | N'-Cbz-L-ornithine Chemical Properties |
| Melting point | 248-252℃ | | Boiling point | 492.2±45.0 °C(Predicted) | | density | 1.234±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Acidic Alcohol (Sparingly), Aqueous Acid (Slightly) | | pka | 2.51±0.24(Predicted) | | form | Solid | | color | White | | InChI | 1S/C13H18N2O4/c14-8-4-7-11(12(16)17)15-13(18)19-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9,14H2,(H,15,18)(H,16,17)/t11-/m0/s1 | | InChIKey | ZYGRWJVRLNJIMR-NSHDSACASA-N | | SMILES | NCCC[C@H](NC(=O)OCc1ccccc1)C(O)=O | | CAS DataBase Reference | 3304-51-6(CAS DataBase Reference) |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | N'-Cbz-L-ornithine Usage And Synthesis |
| Chemical Properties | White powder | | Uses | L-Orn(Z)-OH is used as a reactant in the synthesis of cyclic aminohexapeptides which showed antifungal activity. | | Synthesis | The general procedure for the synthesis of (S)-2-amino-5-(((benzyloxy)carbonyl)amino)pentanoic acid from L-ornithine hydrochloride and benzyl chloroformate was as follows: 7.5 g of L-ornithine hydrochloride was dissolved in 89 mL of 0.5 mol/L sodium hydroxide solution, 5.55 g of anhydrous copper sulfate was added, and the reaction was carried out for 15 minutes. Subsequently, 6.15 g of anhydrous potassium carbonate and 8.2 mL of benzyl chloroformate were added and the reaction mixture was stirred at room temperature overnight. After completion of the reaction, the filtrate was washed to give a blue solid. The solid was treated with saturated disodium ethylenediaminetetraacetic acid solution, which was first heated to reflux for 2 hours and then left at room temperature overnight. Finally, the filtrate was filtered and dried to give a white solid product in 83% yield. | | References | [1] Patent: CN104788431, 2017, B. Location in patent: Paragraph 0055; 0056
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 2009, vol. 52, # 2, p. 29 - 32
[3] Tetrahedron, 1999, vol. 55, # 33, p. 10201 - 10220
[4] Journal of the Chemical Society [Section] C: Organic, 1971, p. 3743 - 3748
[5] Journal of Agricultural and Food Chemistry, 1999, vol. 47, # 3, p. 939 - 944 |
| | N'-Cbz-L-ornithine Preparation Products And Raw materials |
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