| Company Name: |
Shanghai Hanhong Scientific Co.,Ltd.
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| Tel: |
021-54306202 13764082696 |
| Email: |
info@hanhongsci.com |
| Products Intro: |
Product Name:rec GM-CSF (human)
CAS:99283-10-0
Remarks:198P02
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
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| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:rec GM-CSF (huMan); ;rec Granulocyte-Macrophage-Colony StiMulating Factor (huMan)
CAS:99283-10-0
Purity:99% Package:20.0μg
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| Product Name: | MOLGRASTIM | | Synonyms: | HUMAN MGI-1GM;HUMAN GM-CSF;HUMAN GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;HUMAN CSF-2;HUMAN PLURIPOIETIN-ALPHA;GM-CSF, HUMAN;GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR;GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR, HUMAN | | CAS: | 99283-10-0 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | Human | | Mol File: | Mol File | ![MOLGRASTIM Structure]() |
| | MOLGRASTIM Chemical Properties |
| storage temp. | -20°C | | form | lyophilized powder | | color | white to off-white | | biological source | human | | Water Solubility | water: soluble 0.010mL, clear, colorless |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | MOLGRASTIM Usage And Synthesis |
| Chemical Properties | Clear, colourless liquid. | | Uses | Antineutropenic; hematopoietic stimulant. | | Uses | Granulocyte-Macrophage Colony-Stimulating Factor human has been used in the medium for plating of the cells. It has been used in culture medium for the differentiation of human peripheral blood mononuclear cells. | | General Description | Package size based on protein content | | Biochem/physiol Actions | Granulocyte-macrophage colony stimulating factor (GM-CSF) is a growth and differentiation factor for cells in the granulocyte, macrophage and eosinophil lineage. GM-CSF stimulates colony formation from pluripotential progenitor cells at extremely low concentrations and is an essential survival and proliferative factor for hematopoietic progenitor cells in all divisions up to maturity. It also stimulates growth in some epithelial cells and osteoclasts. GM-CSF is produced by a variety of cell types (monocytes, endothelial cells, T-cells, fibroblasts, mitogen-stimulated B-cells, and LPS-stimulated macrophages). GM-CSF is secreted as a single chain glycoprotein containing 128 amino acids for human with a conserved disulfide bond. Human and murine GM-CSF share approx. 54% sequence homology and do not cross-react in bioactivity. | | Description | Granulocyte Macrophage Colony Stimulating Factor Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 127 amino acids and having a molecular mass of 14477 Dalton. GM-CSF is purified by proprietary chromatographic techniques. | | Source | Escherichia Coli | | Background | Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) was first characterized as a growth factor that supports the in-vitro colony formation of granulocytes-macrophages progenitor cells. It is a pleiotropic cytokine and a member of a family of endogenous cytokines of the hematopoietic system. GM-CSF is produced as a response to immune or inflammatory stimuli by activated cells of the hematopoietic system such as T cells, B cells, macrophages, mast cells and also fibroblasts and alveolar epithelial cells. It plays an important role in regulating the proliferation, differentiation, survival and activation of hematopoietic cells such as granulocytes and monocytes ,neutrophiles, basophiles and eosonophoiles, erythroid cells, megakaryocytes and T cells.
Human and mouse GM-CSF have about 56% homology and are species specific. Human GM-CSF is not active on mouse cells and vice versa. It is active on canine and feline cells.
GMCSF is 144 amino acids, 22kDa glycoprotein. It is composed of four bundles alpha helices. Its receptor is heterodimers with a ligand-specific alpha subunit and a betac subunit that is shared with the interleukin IL-3 and IL-5 receptors. This unusual form of receptor assembly likely applies also to IL-3 and IL-5 receptors. Cross-linking the two receptor subunits is required for receptor activation and signaling .
GMCSF has been shown to be involved in maturation, mobilization and antigen presentation of myeloid dentritic cells (DCs) in-vivo or ex-vivo. This function promotes Th1 immune responses, cytotoxcity, anti-angiogenesis as well as allergic inflammation, and the development of autoimmunity. Therefore GMCSF can be used in immunotherapy for the treatment of immune suppressed and immune-compromised patients as well as in veterinary medicine for the same purpose. GM-CSF is also important in regulation of embryo development and pregnancy and specifically in embryo implantation and subsequent development . |
| | MOLGRASTIM Preparation Products And Raw materials |
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