CS-2885
| 中文名稱 | CS-2885 |
|---|---|
| 中文同義詞 | 3-((4-(二甲基氨基)萘-1-基)亞甲基)吲哚啉-2-酮;化合物MAZ51;血管內皮細胞生長因子-C抑制劑;化合物MAZ51,10 MM DMSO 溶液;3-(4-二甲基氨基石腦油-1-亞甲基)-1,3-二氫吲哚-2-酮;MAZ51 ,S0765;化合物CS-2885 |
| 英文名稱 | MAZ51 |
| 英文同義詞 | MAZ51;3-(4-DIMETHYLAMINO-NAPHTHALEN-1-YLMETHYLENE)-1,3-DIHYDRO-INDOL-2-ONE;(3E)-3-{[4-(Dimethylamino)-1-naphthyl]methylene}-1,3-dihydro-2H-indol-2-one;(3E)-3-[[4-(dimethylamino)naphthalen-1-yl]methylidene]-1H-indol-2-one;CS-2885;MAZ51;MAZ-51;MAZ 51;2H-Indol-2-one, 3-[[4-(dimethylamino)-1-naphthalenyl]methylene]-1,3-dihydro-;VEGFR3 Kinase Inhibitor, MAZ |
| CAS號 | 163655-37-6 |
| 分子式 | C21H18N2O |
| 分子量 | 314.38 |
| EINECS號 | |
| 相關類別 | 非標記小分子 |
| Mol文件 | 163655-37-6.mol |
| 結構式 |  |
CS-2885 性質
| 沸點 | 553.917±50.00 °C(Press: 760.00 Torr)(predicted) |
|---|---|
| 密度 | 1.253±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| 儲存條件 | 2-8°C |
| 溶解度 | 二甲基亞砜：11 毫克/毫升 |
| 形態(tài) | 固體 |
| 酸度系數(pKa) | 12.137±0.20(predicted) |
| 顏色 | 橙色 |
| InChI | 1S/C21H18N2O/c1-23(2)20-12-11-14(15-7-3-4-9-17(15)20)13-18-16-8-5-6-10-19(16)22-21(18)24/h3-13H,1-2H3,(H,22,24) |
| InChIKey | VFCXONOPGCDDBQ-UHFFFAOYSA-N |
| SMILES | N1c2c(cccc2)C(=Cc3c4c(c(cc3)N(C)C)cccc4)C1=O |
MAZ51 是一種選擇性的 vascular endothelial growth factor receptor (VEGFR)-3 (Flt-4) tyrosine kinase 的有效抑制劑。MAZ51 通過 Akt/GSK3β 的磷酸化和 RhoA 的激活來誘導神經膠質瘤細胞的細胞圓縮和G2/M細胞周期停滯。 MAZ51 可抑制多種非VEGFR-3表達腫瘤細胞的增殖并誘導其凋亡。
| Target | Value |
|
VEGFR-3
() | |
|
Akt
() | |
|
GSK3β
() | |
|
RhoA
() |
MAZ51 (2.5-10 μM; 24 hours) blocks proliferation and induces apoptosis in a wide variety of tumor cells.
MAZ51 (0.5-50 μM; 25 minutes) has no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ in A431 cells, HEK-293 cells, and PAE cells, respectively.
Cell Proliferation Assay
| Cell Line: | MT450, 1AS, ASM, G, AT6.1, MTLN3, MTLY, NM-081 cells |
| Concentration: | 2.5, 10 μM |
| Incubation Time: | 24 hours |
| Result: | Induced apoptosis in a wide variety of tumor cells. |
Apoptosis Analysis
| Cell Line: | MT450, 1AS, ASM, G, AT6.1, MTLN3, MTLY, NM-081 cells |
| Concentration: | 2.5, 10 μM |
| Incubation Time: | 24 hours |
| Result: | Blocked proliferation in a wide variety of tumor cells. |
MAZ51 (8 mg/kg; i.p.; daily for 15 day) significantly suppresses the growth of MT450 tumors.
| Animal Model: | Wistar Furth rats (bearing MT450 cells) |
| Dosage: | 8 mg/kg |
| Administration: | Intraperitoneal injection; daily for 15 day |
| Result: | Significantly suppressed the growth of MT450 tumors. |
安全信息
| 危險品標志 | Xn,N |
|---|---|
| 危險類別碼 | 22-37/38-41-51/53 |
| 安全說明 | 26-39-61 |
| 危險品運輸編號 | UN 3077 9/PG 3 |
| WGK Germany | WGK 3 |
| 存儲類別 | 11 - 可燃固體 |
| 提供商 | 語言 |
|---|---|
|
英文
|
| 更新日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/07/06 | S0765 | CS-2885 MAZ51 | 163655-37-6 | 5mg | 1170.08元 |
| 2026/07/06 | S0765 | MAZ51 | 163655-37-6 | 10mM (1mL in DMSO) | 1570元 |