6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide Suppliers list
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
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Products Intro: Product Name:SIRT1-IN-1
CAS:352554-02-0
Package:1ml Remarks:T98074
Company Name: Shanghai SuperLan Chemcial Technique Centre  
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Products Intro: Product Name:SIRT1-IN-1
CAS:352554-02-0
Purity:95 Package:1G,5G,10G,50G,100G,1KG
Company Name: Beijing Solarbio Science & Tecnology Co., Ltd.  
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Products Intro: Product Name:SIRT1-IN-1
CAS:352554-02-0
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
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Products Intro: Product Name:SIRT1-IN-1
CAS:352554-02-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
Company Name: Jinan Jiuli Biotechnology Co. , Ltd.  
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Products Intro: Product Name:SIRT1-IN-1
CAS:352554-02-0
Purity:98% Package:500mg；1g；5g
6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide Basic information
Product Name:6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Synonyms:SIRT1-IN-1;6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide;inhibit,Cytomegalovirus,CMV,antiviral,indole,Inhibitor,Sirtuin,SIRT1IN1,SIRT1 IN 1;1H-Carbazole-1-carboxamide, 2,3,4,9-tetrahydro-6-methyl-;SIRT1-IN-1, 10 mM in DMSO
CAS:352554-02-0
MF:C14H16N2O
MW:228.29
EINECS:
Product Categories:
Mol File:352554-02-0.mol
6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide Structure
6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide Chemical Properties
Boiling point 509.3±29.0 °C(Predicted)
density 1.244±0.06 g/cm3(Predicted)
pka16.52±0.20(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide Usage And Synthesis
UsesSIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC50 of 11.5 μM[1]. SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity[2].
IC 50SIRT1: 0.205 μM (IC50); SIRT2: 11.5 μM (IC50); SIRT3: >100 μM (IC50)
References[1] Andrew D Napper, et al. Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54. DOI:10.1021/jm050522v
[2] Thomas Shenk, et al. Sirtuin Modulators as Inhibitors of Cytomegalovirus. US20160296523A1.
6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide Preparation Products And Raw materials
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