7,8-二氫-D-新蝶呤
| 中文名稱 | 7,8-二氫-D-新蝶呤 |
|---|---|
| 中文同義詞 | 7,8-二氫-D-新蝶呤;化合物 7,8-DIHYDRONEOPTERIN;7,8-Dihydroneopterin試劑;7,8-Dihydroneopterin #天然產(chǎn)物 HY-136341;7,8-Dihydroneopterin試劑;7,8-Dihydroneopterin #天然產(chǎn)物 HY-136341 |
| 英文名稱 | 7,8-DIHYDRONEOPTERIN |
| 英文同義詞 | 2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydro-1H-pteridin-4-one;2-azanyl-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydro-1H-pteridin-4-one;Dihydroneopterin;NEOPTERIN, 7,8-DIHYDRO-D;7,8-DIHYDRO-D-NEOPTERIN;7,8-DIHYDRONEOPTERIN;4(3H)-Pteridinone, 2-amino-7,8-dihydro-6-[(1S,2R)-1,2,3-trihydroxypropyl]- |
| CAS號(hào) | 1218-98-0 |
| 分子式 | C9H13N5O4 |
| 分子量 | 255.23 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | 生物活性小分子;Heterocycles, Nucleotides, Bases & Related Reagents, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 1218-98-0.mol |
| 結(jié)構(gòu)式 |  |
7,8-二氫-D-新蝶呤 性質(zhì)
| 熔點(diǎn) | >167°C (dec.) |
|---|---|
| 沸點(diǎn) | 614.6±65.0 °C(Predicted) |
| 密度 | 2.03±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | −20°C |
| 溶解度 | 可溶于酸性水溶液（少許）、DMSO（少許） |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 9.88±0.20(Predicted) |
| 顏色 | 淡黃色低 |
| BRN | 1133875 |
| InChI | 1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1 |
| InChIKey | YQIFAMYNGGOTFB-XINAWCOVSA-N |
| SMILES | NC1=NC(=O)C2=C(NCC(=N2)[C@H](O)[C@H](O)CO)N1 |
7,8-Dihydroneopterin 是一種炎癥標(biāo)記，通過(guò)增強(qiáng)一氧化氮合酶 (iNOS) 的表達(dá)來(lái)誘導(dǎo)星形膠質(zhì)細(xì)胞和神經(jīng)元細(xì)胞凋亡 (apoptosis)?？捎糜谏窠?jīng)退行性疾病的研究。
Apoptosis; iNOS
7,8-Dihydroneopterin is a heterocyclic pteridine which produced and secreted by monocytes/macrophages upon stimulation with the cytokine interferon-y (IFN-y).
7,8-Dihydroneopterin (0.1, 0.5, 1, 2.5, 5 mM; 2 days and 5 days) inhibits growth of U373MG astroeytes .
Cell Viability Assay
| Cell Line: | Astrocytic cell line U373MG |
| Concentration: | 0.1, 0.5, 1, 2.5, 5 mM |
| Incubation Time: | 2 days and 5 days |
| Result: |
After 2 days of treatment, a significantly lower cell number was observed for those cells treated with 5 mM and 2.5 mM.
After incubation for 5 days concentrations of 1-5 mM completely abrogated acid phosphatase activity to background level found for complete cell culture medium. A significant cell growth inhibition was also visible for the cells incubated with 0.5 mM, whereas 0.1 mM did not alter cell growth. |
安全信息
| 提供商 | 語(yǔ)言 |
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英文
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