1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Suppliers list
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:SPP-86
CAS:1357349-91-7
Purity:98.19% Package:1mg;41USD|5mg;97USD|10mg;155USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Zibo Hangyu Biotechnology Development Co., Ltd
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Products Intro: Product Name:1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS:1357349-91-7
Purity:99% Package:mg,g,kg
Company Name: Aladdin Scientific
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Email: tp@aladdinsci.com
Products Intro: Product Name:SPP 86
CAS:1357349-91-7
Purity:>=98%(HPLC) Package:$187.9/10mg;$593.9/50mg;$2673.9/250mg;Bulk package Remarks:98%(HPLC)
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
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Products Intro: Product Name:1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS:1357349-91-7
Purity:98% Package:5mg Remarks:S89397
Company Name: ShangHai Biochempartner Co.,Ltd  
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Products Intro: Product Name:SPP-86
CAS:1357349-91-7
Purity:98% HPLC LCMS Package:100mg;500mg;1g

1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine manufacturers

  • SPP-86
  • SPP-86 pictures
  • $41.00
  • 2026-04-20
  • CAS:1357349-91-7
  • Purity: 99.53%
  • Supply Ability: 10g
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Basic information
Product Name:1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Synonyms:1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;SPP 86;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1-methylethyl)-3-(2-phenylethynyl)-;SPP86 >=98% (HPLC);Inhibitor,inhibit,SPP-86,SPP 86,SPP86,RET;1-Isopropyl-3-(phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;SPP-86, 10 mM in DMSO
CAS:1357349-91-7
MF:C16H15N5
MW:277.32
EINECS:
Product Categories:
Mol File:1357349-91-7.mol
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Structure
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Chemical Properties
Boiling point 495.3±40.0 °C(Predicted)
density 1.23±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka3.95±0.30(Predicted)
form Solid
color Off-white to light yellow
InChI1S/C16H15N5/c1-11(2)21-16-14(15(17)18-10-19-16)13(20-21)9-8-12-6-4-3-5-7-12/h3-7,10-11H,1-2H3,(H2,17,18,19)
InChIKeyJQOIRTDBHMDWMT-UHFFFAOYSA-N
SMILESNC1=NC=NC2=C1C(C#CC3=CC=CC=C3)=NN2C(C)C
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
MSDS Information
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Usage And Synthesis
UsesSPP 86 is a potent RET Kinase inhibitor.
Biological ActivitySPP86 is a potent cell permeable inihbitor of RET tyrosine kinase with an IC50 value of 8 nM and with some inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. SPP86 does not inhibit p38, CSK, KIT, PDGF, Src or BCR-ABL. SPP86 inhibited RET-mediated activation of the PI3K/Akt and MAPK pathways at doses of 0.1- 1 μM in a cell line expressing oncogenic RET and inhibited RET-induced ERα phosphorylation and proliferation in MCF7 cells with an IC50 value of 1.0 μM, similar to tamoxifen.
storageStore at +4°C
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Preparation Products And Raw materials
Tag:1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine(1357349-91-7) Related Product Information