[1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- manufacturers
- SU0268
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- $41.00
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2026-07-13
- CAS:2210228-45-6
- Purity: 99.98%
- Supply Ability: 10g
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| | [1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- Basic information |
| Product Name: | [1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- | | Synonyms: | [1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]-;SU0268;SU-0268 (SU0268);MCF-7,Inhibitor,cGAS,OGG1,SU0268,A549,SU 0268,STING,IRF3,inhibit,HeLa,glycosylase,antibacterial,SU-0268;4'-(N-(1-(Cyclopropanecarbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)sulfamoyl)-[1,1'-biphenyl]-3-carboxamide;SU0268, 10 mM in DMSO | | CAS: | 2210228-45-6 | | MF: | C26H25N3O4S | | MW: | 475.56 | | EINECS: | | | Product Categories: | | | Mol File: | 2210228-45-6.mol | ![[1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- Structure](CAS/20200515/GIF/2210228-45-6.gif) |
| | [1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- Chemical Properties |
| storage temp. | -20°C | | solubility | Soluble in DMSO (10 mg/ml) | | form | solid | | color | Off-white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | [1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- Usage And Synthesis |
| Description | SU0268 (2210228-45-6) is potent (IC50 = 59 nM) inhibitor of the DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1).1,2 Selective versus other DNA repair enzymes (MTH1, DUT, NUDT16, ABH2, ABH3, and SMUG1). SU0268 inhibited proinflammatory responses to Pseudomonas aeruginosa infection in C57BL/6 wild-type mice.3 | | Uses | SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1). SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection[1][2][3]. | | in vivo | SU0268 pretreatment (10 mg/kg, intranasally treated) increases survival rates compared with controls without SU0268 pretreatment in MH-S cells and C57BL/6N mice[3].
| Animal Model: | Anesthetized C57BL/6N mice[3]. | | Dosage: | 10 mg/kg. | | Administration: | Intranasally treated. | | Result: | Significantly inhibits inflammatory responses and mitigates P. aeruginosa infection. |
| | References | [1] YU-KI TAHARA. Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase[J]. Journal of the American Chemical Society, 2018, 140 6: 2105-2114. DOI:10.1021/jacs.7b09316
[2] MELIS KANT. Inhibition by Tetrahydroquinoline Sulfonamide Derivatives of the Activity of Human 8-Oxoguanine DNA Glycosylase (OGG1) for Several Products of Oxidatively induced DNA Base Lesions[J]. ACS Chemical Biology, 2020, 16 1: 45-51. DOI:10.1021/acschembio.0c00877
[3] SHUGANG QIN. Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during Pseudomonas aeruginosa Infection.[J]. ACS Applied Electronic Materials, 2020: 2231-2242. DOI:10.4049/jimmunol.1901533 |
| | [1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- Preparation Products And Raw materials |
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