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| | POTASSIUM 4-BROMOPHENYLTRIFLUOROBORATE Basic information |
| | POTASSIUM 4-BROMOPHENYLTRIFLUOROBORATE Chemical Properties |
| Melting point | >300 °C(lit.) | | storage temp. | Inert atmosphere,Room Temperature | | form | powder to crystal | | color | White to Almost white | | Water Solubility | Soluble in water. | | BRN | 9297533 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 2931900090 |
| | POTASSIUM 4-BROMOPHENYLTRIFLUOROBORATE Usage And Synthesis |
| Uses | Potassium 4-bromophenyltrifluoroborate is used as potent boronic acid surrogates in Suzuki-Miyaura Cross-Coupling reactions. | | Synthesis | GENERAL STEPS: In a reaction vessel equipped with a charging funnel, 4-bromophenylboronic acid (5 mmol) was dissolved in methanol (10 mL). A solution of potassium hydrogen fluoride (KHF2, 1.56 g, 20 mmol) in water (8 mL) was added slowly and dropwise. The reaction mixture was stirred at room temperature for 30 min. Subsequently, the mixture was concentrated under high vacuum to remove the solvent. The residual solid was extracted with an acetone solution of 20% methanol (4 x 10 mL). The extracts were combined, concentrated to near saturation, and then ether (Et2O) was added until no further precipitate was produced. The precipitate was collected by filtration, washed with ether (2 × 10 mL), and finally dried under high vacuum to give a potassium 4-bromophenyl trifluoroborate product of sufficient purity for subsequent characterization. | | References | [1] Journal of the American Chemical Society, 2008, vol. 130, # 47, p. 15792 - 15793
[2] Tetrahedron Letters, 2012, vol. 53, # 32, p. 4240 - 4242 |
| | POTASSIUM 4-BROMOPHENYLTRIFLUOROBORATE Preparation Products And Raw materials |
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