AG 99 manufacturers
- (E)-AG 99
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- $35.00
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2026-07-27
- CAS:122520-85-8
- Purity: 99.67%
- Supply Ability: 10g
- AG 99
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- $1.00
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2019-12-27
- CAS:122520-85-8
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 200kg
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| Product Name: | AG 99 | | Synonyms: | TYRPHOSTIN B40;TYRPHOSTIN 46;TYRPHOSTIN A46;3,4-DIHYDROXY-ALPHA-CYANOCINNAMIDE;ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMIDE;AG 99;(E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide;(E)-2-Cyano-3-(3,4-dihydroxyphenyl)propenamide | | CAS: | 122520-85-8 | | MF: | C10H8N2O3 | | MW: | 204.18 | | EINECS: | | | Product Categories: | ALCOHOL;Intracellular Signaling | | Mol File: | 122520-85-8.mol |  |
| | AG 99 Chemical Properties |
| Melting point | 247 °C | | Boiling point | 544.4±50.0 °C(Predicted) | | density | 1.482±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Soluble in DMSO | | pka | 8.81±0.10(Predicted) | | form | Brown solid. | | color | Light yellow to yellow | | InChI | InChI=1S/C10H8N2O3/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+ | | InChIKey | USOXQZNJFMKTKJ-XVNBXDOJSA-N | | SMILES | C(N)(=O)/C(/C#N)=C/C1=CC=C(O)C(O)=C1 |
| | AG 99 Usage And Synthesis |
| Uses | Tyrphostin AG 99 is a potent, cell-permeable and reversible inhibitor of EGFR and EGF-dependent cell proliferation. | | Biological Activity | Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 10 μ M) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145 met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro . | | IC 50 | EGFR | | references | [1]. gazit a, osherov n, gilon c, et al. tyrphostins. 6. dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of egf receptor tyrosine kinase in vitro. j med chem, 1996, 39(25): 4905-4911.
[2]. yamamoto n, mammadova g, song rx, et al. tyrosine phosphorylation of p145met mediated by egfr and src is required for serum-independent survival of human bladder carcinoma cells. j cell sci, 2006, 119(pt 22): 4623-4633. |
| | AG 99 Preparation Products And Raw materials |
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