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D-Methionine

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D-Methionine manufacturers

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  • CAS:348-67-4
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  • CAS:348-67-4
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  • 2021-11-02
  • CAS:348-67-4
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D-Methionine Basic information
Product Name:D-Methionine
Synonyms:D-2-AMINO-4-[METHYLTHIO]BUTANOIC ACID;d-2-amino-4-(methylthio)butyric acid;D-LOBAMINE;D-METHIONINE;D-BANTHIONINE;(R)-2-AMINO-4-(METHYLMERCAPTO)BUTYRIC ACID;(2R)-2-Amino-4-methylsulfanylbutanoic acid;D-Methionine (H-D-Met-OH)
CAS:348-67-4
MF:C5H11NO2S
MW:149.21
EINECS:206-483-6
Product Categories:PROTECTED AMINO ACID & PEPTIDES;Methionine [Met, M];Amino ACIDS SERIES;Amino Acid Derivatives;Amino Acids and Derivatives;Amino Acids and Derivatives;Amino Acids
Mol File:348-67-4.mol
D-Methionine Structure
D-Methionine Chemical Properties
Melting point 273-275 °C
Boiling point 306.9±37.0 °C(Predicted)
alpha -24 º (c=8, 6N HCl)
density 1.113 (estimate)
refractive index 1.5216 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility 53 g/L (20°C)
pka2.23±0.10(Predicted)
form Powder
color White to off-white
Water Solubility 53 g/L (20 ºC)
Merck 14,5975
BRN 1722293
Stability:Stable. Incompatible with strong oxidizing agents.
Major Applicationcell analysis
peptide synthesis
InChI1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m1/s1
InChIKeyFFEARJCKVFRZRR-SCSAIBSYSA-N
SMILESCSCC[C@@H](N)C(O)=O
LogP0.370 (est)
CAS DataBase Reference348-67-4(CAS DataBase Reference)
NIST Chemistry ReferenceD-(l)-Methionine(348-67-4)
EPA Substance Registry SystemD-Methionine (348-67-4)
Safety Information
Hazard Codes Xi
Risk Statements 33-36/37/38
Safety Statements 22-24/25-36-26
WGK Germany 3
RTECS PD0455000
TSCA TSCA listed
HS Code 29304090
Storage Class11 - Combustible Solids
MSDS Information
ProviderLanguage
(R)-2-Amino-4-(methylmercapto)butyric acid English
SigmaAldrich English
ACROS English
ALFA English
D-Methionine Usage And Synthesis
Chemical PropertiesWhite crystalline powder
UsesD-Methionine is used to rescue noise-induced hearing loss. It is used to improve the nutritive value of animal feed.
DefinitionChEBI: An optically active form of methionine having D-configuration.
Biochem/physiol ActionsD-methionine has been shown to rescue noise-induced hearing loss.
Synthesis
N-Acetyl-D-methionine

1509-92-8

D-Methionine

348-67-4

The general procedure for the determination of N-d-AAase activity using N-acetyl-D-methionine as substrate was as follows: first, N-d-AAase was incubated with N-acetyl-D-methionine at 4°C. Subsequently, a colorimetric solution mixture containing d-amino acid oxidase (coupled with horseradish peroxidase), peroxidase (10 U/mL), 4-aminoantipyrine (0.04 mg/mL) and phenol (0.8 mM) was added. Absorbance (OD) was measured at 520 nm. The unit of enzyme activity was defined as the amount of catalytic production of 1 μmol D-methionine per minute. Protein concentration was determined by the Bradford method using bovine serum albumin as standard [32]. The kinetic parameters kcat and Km were determined by fitting the initial rate as a function of substrate concentration to the Michaelis-Menten equation.

References[1] Journal of the American Chemical Society, 1953, vol. 75, p. 4058
[2] Journal of Biological Chemistry, 1952, vol. 194, p. 455,458
[3] Journal of the American Chemical Society, 1951, vol. 73, p. 4604
[4] Bulletin of the Agricultural Chemical Society of Japan, 1957, vol. 21, p. 235,237
[5] Bioscience, biotechnology, and biochemistry, 1992, vol. 56, # 9, p. 1392 - 1395
Tag:D-Methionine(348-67-4) Related Product Information
4-Aminobutyric acid L-Methionine Zinc methionine sulfate ISOMETHIOZIN Molasses 6-Aminocaproic acid Butyric Acid DL-Methionine D-(-)-Asparagine monohydrate D(-)-Glutamic acid D-2-Amino-4-methylpentanoic acid Glycine S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt BOC-D-Methionine D-ETHIONINE N-Cbz-L-methionine Ammonia H-D-MET-OME HCL