化合物 T32535
| 中文名稱 | 化合物 T32535 |
|---|---|
| 中文同義詞 | 化合物L(fēng)ADOSTIGIL;化合物L(fēng)ADOSTIGIL,10 MM DMSO 溶液 |
| 英文名稱 | LADOSTIGIL |
| 英文同義詞 | LADOSTIGIL;Ladostigil (TV-3,326);LHXOCOHMBFOVJS-OAHLLOKOSA-N;Carbamic acid, N-ethyl-N-methyl-, (3R)-2,3-dihydro-3-(2-propyn-1-ylamino)-1H-inden-5-yl ester;TV-3326|||Ladostigil|||TV 3326|||TV3326|||Ladostigil free base;Ladostigil, 10 mM in DMSO |
| CAS號(hào) | 209394-27-4 |
| 分子式 | C16H20N2O2 |
| 分子量 | 272.34 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 209394-27-4.mol |
| 結(jié)構(gòu)式 |  |
化合物 T32535 性質(zhì)
| 沸點(diǎn) | 412.4±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.14±0.1 g/cm3(Predicted) |
| 酸度系數(shù)(pKa) | 6.94±0.20(Predicted) |
|
MAO-B 37.1 μM (IC 50 ) |
AChE 31.8 μM (IC 50 ) |
Ladostigil (1-10 μM) exerts neuroprotective activities, including a prevention of the fall of the mitochondrial membrane potential (ψ), attenuation of apoptotic cascades and an inhibition of ROS production induced by OS insults.
Ladostigil (1-10 μM) has a significant neuroprotective activity, including inhibition of caspase-3 activation, induction of Bcl-2 and reduction of Bad and Bax gene and protein expression in human neuroblastoma SK-N-SH cells.
Ladostigil (17 mg/kg; p.o. daily for 6 weeks) abolishes their hyperanxiety and depressive-like behaviour in the elevated plus maze (EPM) and forced swim tests (FST) tests in adulthood from puberty to prenatally-stressed rats.
Ladostigil (50 μmol/kg; single p.o.) restores the loss of episodic memory in the object recognition test in rats.
| Animal Model: | Pathogen-free (SPF) Sprague-Dawley rats |
| Dosage: | 17 mg/kg |
| Administration: | P.o. (added to the drinking water) daily for 6 weeks |
| Result: |
Inhibited brain MAO-A and B by more than 60%.
Reduced hyperanxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-10399 | 化合物 T32535 Ladostigil | 209394-27-4 | 1 mg | 2045元 |
| 2026/06/05 | HY-10399 | 化合物 T32535 Ladostigil | 209394-27-4 | 5mg | 4500元 |