4(1H)-Pyrimidinone, 2-amino-6-methyl-5-nitro- manufacturers
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| | 4(1H)-Pyrimidinone, 2-amino-6-methyl-5-nitro- Basic information |
| Product Name: | 4(1H)-Pyrimidinone, 2-amino-6-methyl-5-nitro- | | Synonyms: | 4(1H)-Pyrimidinone, 2-amino-6-methyl-5-nitro-;2-AMINO-4-HYDROXY-5-NITRO-6-METHYL-PYRIMIDINE;2-Amino-6-methyl-5-nitro-3H-pyrimidine-4-one;2-amino-6-methyl-5-nitro-1H-pyrimidin-4-one;2-azanyl-6-methyl-5-nitro-1H-pyrimidin-4-one;2-amino-6-methyl-5-nitropyrimidin-4(1H)-one;2-Amino-6-methyl-5-nitro-4(3H)-pyrimidinone;2-amino-4-hydroxy-6-methyl-5-nitropyrimidine | | CAS: | 4214-85-1 | | MF: | C5H6N4O3 | | MW: | 170.13 | | EINECS: | | | Product Categories: | Pyrimidine series | | Mol File: | 4214-85-1.mol |  |
| | 4(1H)-Pyrimidinone, 2-amino-6-methyl-5-nitro- Chemical Properties |
| Melting point | >300 °C | | Boiling point | 305.9±45.0 °C(Predicted) | | density | 1.83±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C, protect from light | | pka | 7.18±0.50(Predicted) | | Appearance | Light yellow to yellow Powder |
| HazardClass | IRRITANT | | HS Code | 2933599590 |
| | 4(1H)-Pyrimidinone, 2-amino-6-methyl-5-nitro- Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 2-amino-6-methyl-5-nitro-3H-pyrimidin-4-one from 2-amino-4-hydroxy-6-methylpyrimidine was as follows: 2-amino-6-methylpyrimidin-4(3H)-one (50 g, 0.4 mol) was dissolved in 250 mL of concentrated sulfuric acid at 0°C, and 40 mL of concentrated nitric acid was slowly added through a dropping funnel. The reaction mixture was stirred at room temperature for 3 hours and then slowly poured into 3.6 L of diethyl ether and continued stirring for 15 minutes. The ether layer was decanted off and 1.0 L of ethyl acetate was added to the remaining solid and stirred for 10 hours. The solid product (54.8 g, 81% yield) was collected by filtration, which could be used in subsequent reactions without further purification. | | References | [1] Synthetic Communications, 2009, vol. 39, # 12, p. 2244 - 2249
[2] Journal of Heterocyclic Chemistry, 2009, vol. 46, # 6, p. 1151 - 1153
[3] Journal of Organic Chemistry, 1995, vol. 60, # 24, p. 7947 - 7952
[4] Patent: WO2006/122003, 2006, A2. Location in patent: Page/Page column 32; 34
[5] Nucleosides and Nucleotides, 1999, vol. 18, # 3, p. 363 - 376 |
| | 4(1H)-Pyrimidinone, 2-amino-6-methyl-5-nitro- Preparation Products And Raw materials |
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