| Company Name: |
Guangzhou Younan Technology Co., Ltd
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| Tel: |
020-82000279 18988941452 |
| Email: |
YN_research@163.com |
| Products Intro: |
Product Name:p-Toluic acid-d
CAS:2276-94-0
Purity:95+/98+ Package:25mg;100mg;500mg;1g;5g
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 15002144251 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Allolithocholic acid
CAS:2276-94-0
Purity:98.00% Package:1mg/RMB 892
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| Company Name: |
LGC Science (Shanghai) Ltd.
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| Tel: |
17717235263 |
| Email: |
fan.yang@lgcgroup.com |
| Products Intro: |
Product Name:Allolithocholic acid
CAS:2276-94-0
Purity:具體純度，見COA Package:100mg Remarks:TRC-A128920
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Allolithocholic acid manufacturers
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| | Allolithocholic acid Basic information |
| Product Name: | Allolithocholic acid | | Synonyms: | (4R)-4-[(3R,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid;Allocholic Acid Impurity 2;Cholan-24-oic acid, 3-hydroxy-, (3α,5α)-;Allolithocholic acid (ALCA);Cholan-24-oic acid,3-hydroxy-, (3a,5a)-;p-Toluic acid-d;ALLOLITHOCHOLIC ACID;Allolithocholic acid (Standard) | | CAS: | 2276-94-0 | | MF: | C24H40O3 | | MW: | 376.58 | | EINECS: | | | Product Categories: | | | Mol File: | 2276-94-0.mol |  |
| | Allolithocholic acid Chemical Properties |
| Melting point | 204-208 °C | | Boiling point | 511.0±23.0 °C(Predicted) | | density | 1.073±0.06 g/cm3(Predicted) | | storage temp. | -20°C (-15°C to -25°C) | | solubility | DMSO: Slightly soluble; Ethanol: Slightly soluble; Methanol: Slightly soluble | | form | A solid | | pka | 4.76±0.10(Predicted) | | color | White to off-white |
| WGK Germany | WGK 3 | | Storage Class | 13 - Non Combustible Solids |
| | Allolithocholic acid Usage And Synthesis |
| Uses | Allolithocholic acid is used as steroid compound as T regulatory lymphocyte modulators and uses for treatment of inflammatory or autoimmune disorders. | | Definition | ChEBI: Allolithocholic acid is a bile acid. | | Biological Activity | Allolithocholic acid is a secondary allomonohydroxy bile acid.1 It activates large-conductance calcium-activated potassium channels (BK/KCas; EC50 = 44.21 μM in Xenopus oocytes expressing the rat channel). Fecal levels of allolithocholic acid are increased in patients with colorectal cancer.2 Allolithocholic acid has also been found in the urine of infants with biliary atresia.3 | | References | 1. Bukiya, A.N., McMillan, J., Parrill, A.L., et al. Structural determinants of monohydroxylated bile acids to activate β1 subunit-containing BK channels. J. Lipid Res. 49(11), 2441-2451 (2008).https://doi.org/10.1194/jlr.M800286-JLR200
2. Tadano, T., Kanoh, M., Kondoh, H., et al. Kinetic analysis of bile acids in the feces of colorectal cancer patients by gas chromatography-mass spectrometry (GC-MS). Rinsho Byori. 55(5), 417-427 (2007).
3. Makino, I., Sj?vall, J., Norman, A., et al. Excretion of 3β-hydroxy-5-cholenoic and 3ɑ-hydroxy-5ɑ-cholanoic acids in urine of infants with biliary atresia. FEBS Lett. 15(2), 161-164 (1971).https://doi.org/10.1016/0014-5793(71)80047-9 |
| | Allolithocholic acid Preparation Products And Raw materials |
| Raw materials | (4R)-4-[(3S,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid |
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